No registrations found.
ID
Source
Brief title
Health condition
COVID-19
Sponsors and support
Intervention
Outcome measures
Primary outcome
Incidence of neurological symptoms
Secondary outcome
Respiratory failure requiring mechanical ventilation
Background summary
The global outbreak of coronavirus disease 2019 (COVID-19), declared a pandemic by the World Health Organization (WHO) on March 11, 2020, is regarded as the greatest challenge for healthcare in decades. Nervous system involvement in this disease could, rather than an irrelevant side issue, be a piece in the puzzle of understanding why some patients experience rapid progression to respiratory failure not anticipated from their pulmonary status.
In this prospective cohort study involving patients who are/were treated by the COVID team in Zuyderland Medisch Centrum, questionnaire research supplemented by neurological examination will be used to research whether the incidence of neurological symptoms in COVID-19 patients is different from non-COVID-19 patients, and whether neurological symptoms in COVID-19 patients have predictive value for the development of secondary clinical deteriation with respiratory failure.
Study objective
1) The incidence of neurological symptoms is higher in COVID-19 patients than in non-COVID-19 patients.
2) The incidence of progression to respiratory failure is higher in COVID-19 patients with neurological symptoms as compared to COVID-19 patients without neurological symptoms.
Study design
Upon inclusion, upon discharge or transfer to ICU
Inclusion criteria
• Patients who are, or were, treated by the COVID medical team of Zuyderland Medisch Centrum due to one or more complaints because of which they were suspected of COVID-19 as per local hospital protocol
• Classified as either confirmed or negative COVID-19, based upon the contemporary WHO case definition, or investigations ordered to reach one of these classifications
• Age ≥18 years
• Capable of adequately answering questions about neurological symptoms
Exclusion criteria
• Patients in whom no definitive classification of COVID-19 status (confirmed or negative) has been reached
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8536 |
| Other | METC Z : METCZ20200077 |