No registrations found.
ID
Source
Health condition
(non-infectious) ocular inflammation, uveitis, age related macular degeneration, inflammatory corneal disease, idiopathic inflammatory orbital disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
We aim to employ an "omics"-driven systems biology approach on patients with ocular inflammation in order to identify the molecular pathways underlying the pathogenesis of ocular and orbital inflammation and develop clinically usefull markers to predict disease outcome and treatment responses (eg biomarkers). For this we study multiple layers of the immune system (genome, epigenome, proteome, metabolome and cellsubsets).
Secondary outcome
To identify new therapeutical targets for potential use in future clinical studies by evaluation of novel biomarkers in functional models
Study objective
A systems biology approach is an hypothesis free study that looks at multiple layers within one patient (genome, epigenome, proteome, metabolome)
Study design
Venous blood is drawn at active inflammation
Intervention
none (observational)
University Medical Centre Utrecht
Jonas Kuiper
Heidelberglaan 100 3584 CX Utrecht
Utrecht
The Netherlands
+31 (0)88 7553569
j.j.w.kuiper@umcutrecht.nl
University Medical Centre Utrecht
Jonas Kuiper
Heidelberglaan 100 3584 CX Utrecht
Utrecht
The Netherlands
+31 (0)88 7553569
j.j.w.kuiper@umcutrecht.nl
Inclusion criteria
- 18-95 years of age
- diagnosed with non-infectious uveitis (anterior, intermediate, posterior, panuveitis, scleritis) OR
- inflammatory corneal disease (keratokonus, Fuchs endothelial corneal dystrophy) OR
- idiopathic inflammatory orbital disease OR
- age-related macular degeneration
Exclusion criteria
- (acquired) immune deficiencies
- inadequate knowledge of Dutch
- current use of systemic immunomodulatory agents, biologicals or cyclosporine
- IV corticosteroids in last 14 days before inclusion
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4512 |
| NTR-old | NTR4630 |
| Other | ABR: NL46874.041.13 : METC: 14/065 |