No registrations found.
ID
Source
Brief title
Health condition
infectious diseases, influenza, viral and bacterial co-infections, carriage
(in Dutch: infectieziekten, griep, virale en bacteriele infecties, dragerschap)
Sponsors and support
Intervention
Outcome measures
Primary outcome
Presence of influenza A and B virus in nasal swab during ILI episodes.
Secondary outcome
1. Subtyping of influenza viruses in case of influenza infection;
2. Antibody levels to influenza virus;
3. Presence of viral (other than influenza A or B) and bacterial microorganisms in nasal and transoral
nasopharyngeal swabs respectively after reporting of ILI by the participants during ILI episodes and 8 weeks later. The following micro-organisms will at least be screened by PCR or conventional bacterial culture: human parainfluenza virus, RSV A and B, adenovirus, coronavirus, hMPV, human rhinovirus, bocavirus and polyomaviruses, Mycoplasma
pneumoniae, S. pneumoniae, H. influenzae, M. catarrhalis, S. aureus, N. meningitidis and B. pertussis. Other pathogens might be added if diagnosis is still inconclusive or if other pathogens become prevalent during this season. Additional
pneumococcal serotyping may be performed by multiserotype PCR;
4. Presence of S. pneumoniae in saliva;
5. Antibody levels towards viral and bacterial pathogens present in the swabs as identified by PCR or bacterial culture;
6. A SF-36 (short-form health survey) questionnaire at baseline.
Background summary
The general public is questioning the effectiveness of seasonal influenza vaccination in elderly as a result of the general impression that all influenza-like illness (ILI) is caused by an influenza virus infection. However, several pathogens, both viral and bacterial, can cause ILI. A better understanding of the percentage of ILI caused by an influenza virus infection and the contribution of other respiratory viruses or involvement of bacteria will allow a better appreciation of seasonal influenza vaccines. In addition, information will be collected on the occurrence of viral and bacterial co-infections.
Study objective
Influenza-like-illness (ILI) is not only caused by an influenza virus infection, but also by other pathogens, both viral and bacterial. In this study nose and throat swab samples will be taken during ILI episodes to identify pathogens causing ILI in the elderly population.
Study design
Timepoint 1: Within 72 hours after onset of fever and at least 1 other ILI symptom;
Timepoint 2: 8 weeks after timepoint 1;
Extra timepoint: Any timepoint in subjects who do not (yet) have ILI symptoms during the influenza season.
Intervention
N/A
R.A.J. Boxtel, van
Bilthoven 3721 MA
The Netherlands
+31 (0)30 2742755
renee.van.boxtel@rivm.nl
R.A.J. Boxtel, van
Bilthoven 3721 MA
The Netherlands
+31 (0)30 2742755
renee.van.boxtel@rivm.nl
Inclusion criteria
1. ≥ 60 years of age;
2. Willing to present when influenza-like-illness (ILI) symptoms occur;
3. Signed Informed Consent.
Exclusion criteria
N/A
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3234 |
| NTR-old | NTR3386 |
| Other | ABR / protocol ID : 37392 / VAC-261; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |