No registrations found.
ID
Source
Health condition
Septic Shock or dynamic hemodynamic profiles
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Bias, percision, limits of agreement;
2. Percentage of error, Bland altman plot.
Grouped measurements of cardiac output derived from PAC and waveform analysis are performed in triplets, and averaged. Before and after therapeutic interventions in ICU, before and after fluid challenge, before and after changing inotropes, like vasodialition drugs.
Secondary outcome
N/A
Background summary
During the progress of organ failure in critical ill patients often it is unclear whether the patient is adequately fluid resuscitated. To facilitate optimal fluid resuscitation cardiac output is measured by either using an invasive pulmonary artery catheter or a less invasive device. A new minimal invasive technique has become available. Cardiac output measured by arterial pressure waveform (APCO) analysis without manual calibration, the FloTrac/VigileoTM system Edwards Lifesciences. Since its launch there have been three software updates. The cardiac output derived from the arterial waveform analysis of the two latest versions showed good agreements when compared to pulmonary artery catheter under stable haemodynamic conditions [1,2]. In septic shock the bias has been improved with introduction of the 1.10 version of the software (unpublished data). Only recently the newest software version has been released (3.02).
The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using intermitted thermodilution cardiac output in critical ill patients.
Study objective
The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using intermitted thermodilution cardiac output in critical ill patients.
Study design
Power analysis after 8 patients.
Intervention
N/A
Department of Anesthesiology
Marcel A Leeuw, de
Koningin Julianaplein 58
Zaanstad 1502 DV
The Netherlands
+ 31 75-6425529
ma.deleeuw@planet.nl
Department of Anesthesiology
Marcel A Leeuw, de
Koningin Julianaplein 58
Zaanstad 1502 DV
The Netherlands
+ 31 75-6425529
ma.deleeuw@planet.nl
Inclusion criteria
1. Sinus Rhythm;
2. Septic Shock;
3. Inotropic support including Noradrenalin;
4. PA Catheter;
5. Informed consent.
Exclusion criteria
1. Non sinus rhythm;
2. No informed consent.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1954 |
| NTR-old | NTR2072 |
| Other | METC Noord Holland : M09-035 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |