No registrations found.
ID
Source
Brief title
Health condition
1. Angina;
2. angioplasty;
3. electrical neurostimulation;
4. coronary collaterals.
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary endpoint was collateral perfusion, the Pw/Pa ratio. This was measured during a 1-minute balloon inflation during PCI. The Pw/Pa ratio was measured in each patient during two ischemic episodes. To compare the Pw/Pa ratio with and without electrical neurostimulation. The Pw/Pa ratio is measured intracoronary, using a pressure wire.
Secondary outcome
N/A
Background summary
Electrical neurostimulation can be used to treat patients with refractory angina, it reduces angina and ischemia. Previous data have suggested that electrical neurostimulation may alleviate myocardial ischaemia through increased collateral perfusion. We investigated the effect of electrical neurostimulation on functional collateral perfusion, assessed by distal coronary pressure measurement during acute coronary occlusion. We sought to study the effect of electrical neurostimulation on collateral perfusion in a cross-over design.
Methods:
Sixty patients with stable angina and significant coronary artery disease planned for elective percutaneous coronary intervention were split in two groups. In all patients two balloon inflations of 60 seconds were performed, the first for balloon pre-dilatation of the lesion (first episode), the second for stent delivery (second episode). The Pw/Pa ratio (wedge pressure / aortic pressure) was measured during both ischaemic episodes. Group 1 received active neurostimulation during the first episode, group 2 received active neurostimulation during the second episode.
Study objective
Neurostimulation can improve collateral perfusion measured as a Pw/Pa ratio, during acute coronary occlusione.
Study design
N/A
Intervention
The intervention was electrical neurostimulation, during 5 minutes before and during the 1-minute ischemic episode. Within a patient we measured during the 1-minute ischemic episode the collateral perfusion, with and without electrical neurostimulation. The ischemic episode was established by balloon inflation during elective PCI.
Hanzeplein 1
J. Vries, de
Groningen 9713 GZ
The Netherlands
j.de.vries@thorax.umcg.nl
Hanzeplein 1
J. Vries, de
Groningen 9713 GZ
The Netherlands
j.de.vries@thorax.umcg.nl
Inclusion criteria
1. Patients with stable angina;
2. Evidence of myocardial ischemia;
3. Planned for elective percutaneous coronary intervention.
Exclusion criteria
1. Recent myocardial infarction;
2. Prior coronary artery bypass grafting;
3. Undtable angina;
4. Conduction disturbances;
5. Pacemaker;
6. Internal cardio defibrillator.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL933 |
| NTR-old | NTR958 |
| Other | : |
| ISRCTN | ISRCTN81465865 |