No registrations found.
ID
Source
Brief title
Health condition
Parkinson's disease and atypical Parkinsonism.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Comparison of the test results correlate with risk of falling, vestibular complaints or disease progression.
Secondary outcome
1. Correlation of the test results with future fall risk;
2. Prevalence of vestibular disorders in Parkinson's disease or atypical variants.
Background summary
The neurovestibular system of patients with Parkinson’s disease and atypical Parkinsonisms (like PSP, MSA, vascular parkinsonism and cortico-basal syndrome) are studied clinically (clinical examination and questionnaires) and by neurophysiologic testing (VEMP, BAEP, ENG and SVV). Patients and healthy volunteers are invited to participate in this study. The primary aim of this study is to have a better understanding of the neurovestibular pathofysiological mechanisms contributing to falling in parkinson’s disease and atypical parkinsonisms and to evaluate vestibular complaints in these patients.
Study objective
1. Different neuropathological mechanisms in Parkinson's disease and atypical Parkinsonism concerning the risk of falling;
2. Research concerning the diagnostic accuracy and sensitivity of VEMP and SVV.
Study design
1. First year: 50 inclusions;
2. Second: 100 inclusions;
3. Third: 150 inclusions.
Intervention
1. BAEP;
2. ENG;
3. VEMP;
4. SVV;
5. Questionnaire.
(Total duration: 2,5 hours, only 1 visit)
Weg door Jonkerbos 100<br>
Postbus 9015
J. Venhovens
Nijmegen 6500 GS
The Netherlands
j.venhovens@cwz.nl
Weg door Jonkerbos 100<br>
Postbus 9015
J. Venhovens
Nijmegen 6500 GS
The Netherlands
j.venhovens@cwz.nl
Inclusion criteria
1. Age > 18 years;
2. Parkinson's disease, atypical variants (MSA, PSP, CBS and vascular) or healthy control.
Exclusion criteria
1. No cognitive problems;
2. Doesn't use hypnotica, sedativa or anxiolytica;
3. No other known neuro-oto-ophthalmological problems.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3770 |
| NTR-old | NTR3928 |
| Other | METC Regio Arnhem/Nijmegen : 2012/393 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |