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ID
Source
Brief title
Health condition
Post-intensive care syndrome
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Feasibility of the measurement protocol; 2. Maximal exercise capacity; 3. Perceived physical functioning
Secondary outcome
1. Muscle function; 2. Daily activity; 3. Health-related quality of life; 4. Fatigue; 5. Endurance capacity; 6. Dietary intake/screening for malnutrition; 7. Return to work; 8. Mental function; 9. Cognitive function
Background summary
Rationale: Several studies evaluated the deleterious effect of critical illness on physical functioning, with exercise limitations and neuromuscular abnormalities, during and shortly after hospital discharge. As survival rates improve among critically ill patients, there is a growing need to also understand the long-term effects. This information is currently lacking, but crucial for the development of optimal rehabilitation strategies for critical illness survivors after hospital discharge. Therefore, we aim to set up a large prospective longitudinal study to describe the exercise capacity and physical functioning of critical illness survivors up to 5 years after discharge from the Intensive Care Unit (ICU) and to explore potential determinants. To determine the feasibility of the measurement protocol, we will first conduct a cross-sectional feasibility study, including critical illness survivors in different phases of their recovery.
Objective: This project aims to obtain more insight into the feasibility of the measurement protocol of a large prospective longitudinal study to describe the exercise capacity and physical functioning of critical illness survivors up to 5 years after discharge from the ICU.
Study objective
To determine the feasibility of the measurement protocol of a large prospective longitudinal study to describe the exercise capacity and physical functioning of critical illness survivors up to 5 years after discharge from the ICU.
Study design
0-5 years post-ICU discharge
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
• Admitted to an ICU.
• Mechanically ventilated ≥ 24 hours.
• Discharged alive from the ICU.
• Minimum age of 18 years.
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
• Contraindication for being physically active (according to the guidelines by the American College of Sports Medicine).
• Documented history of neurologic disease or psychiatric disease or significant cognitive impairment.
• Unable to follow verbal or written instructions.
• Insufficient mastery of the Dutch language.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL8780 |
| Other | METC AMC : METC2019_238 |