No registrations found.
ID
Source
Health condition
Opioid use, pain
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study endpoint is the opioid requirement in Morphine Equivalent Units (MEU) between individual subjects who received additional paracetamol and those who did not.
Secondary outcome
Secondary outcome is the NRS measured an hour after administration of the opioid and at discharge, between individual subjects who received additional paracetamol at the ED and those who did not.
Background summary
Rationale:
In 2013 about 1.8 million patients visited an ED in the Netherlands, of whom approximately 30.000 attended the AMC. About 50-79% of all patients in the ED complained about pain, and in approximately 40% of these patients, pain was not treated properly.
Of all therapeutically used drugs, opioid analgesics are most frequently associated with adverse drug events. Combining drugs with different mechanisms of action may have an additive or synergistic effect and may lead to a reduction in adverse events. Adjacent paracetamol showed a decrease of approximately 20 to 25% in opioid requirements, postoperatively.
Study objective
The use of paracetamol reduces total opioid requirement in the ED and during the first 24 hours.
Study design
-
Intervention
-
Afdeling Spoedeisende Geneeskunde
Academisch Medisch Centrum
Meibergdreef 9
M.L. Ridderikhof
Amsterdam 1105 AZ
The Netherlands
020-5663333
M.L.Ridderikhof@amc.uva.nl
Afdeling Spoedeisende Geneeskunde
Academisch Medisch Centrum
Meibergdreef 9
M.L. Ridderikhof
Amsterdam 1105 AZ
The Netherlands
020-5663333
M.L.Ridderikhof@amc.uva.nl
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- patients 18 years or older presenting to the ED in the AMC
- an NRS of 4 or higher during presentation
- patients having received an opioid prehospitally (usually in the ambulance) or in the ED
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- hepatic dysfunction
- not capable of reporting their NRS during presentation
- chronic use of analgesics
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6572 |
| NTR-old | NTR6958 |
| Other | : W18_015. METC, AMC, Amsterdam |