No registrations found.
ID
Source
Brief title
Health condition
Sarcopenia
Sponsors and support
Intervention
Outcome measures
Primary outcome
• Type II muscle fiber size (muscle biopsy)
Secondary outcome
• Muscle fiber vascularization (muscle biopsy)
• Muscle microvascular perfusion (CEUS)
• Whole-body skeletal muscle mass (MRI)
• Whole-body and regional body lean tissue mass (DEXA)
• Muscular strength (1 RM – each exercise machine)
• Aerobic capacity (VO2peak cycling test)
• Physical performance (short physical performance battery, timed up-and-go, handgrip strength)
• Metabolic health (OGTT)
• Acute muscle satellite cell response to a single bout of exercise (muscle biopsy)
Background summary
Aging is accompanied by the loss of muscle mass, resulting in a decrease in overall health and function in seniors. This loss can partly be explained by an age-related reduction in muscle perfusion. This study will investigate if endurance exercise training can restore the impaired muscle perfusion to improve muscle mass maintenance and health in older adults.
Study objective
The aerobic pre-conditioning will increase muscle perfusion and thereby improve muscle hypertrophy during the subsequent resistance training program.
Study design
- Pre-endurance training
- Post-endurance training = pre-resistance training
- Post-resistance training
Intervention
- Endurance exercise (if allocated to intervention group)
- Resistance exercise (all participants)
Inclusion criteria
• Age between 65 and 85 y
• BMI between 18.5 and 30 kg/m2
Exclusion criteria
• HbA1C level above 6.5%
• Fasted blood glucose level above 6.9 mmol/L and/or 2 hour OGTT glucose level higher than 11.1 mmol/L
• Smoking
• Diabetes
• Cancer
• Cardiovascular disease
• Arthritic conditions
• A history of neuromuscular problems
• Cognitive Impairment
• COPD
• Renal disorder
• Participation in any structured exercise program
• Hypertension, high blood pressure that is above 140/90 mmHg
• Pulmonary disease
• Known allergic reaction to ultrasound contrast-agent
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7439 |
| NTR-old | NTR7681 |
| Other | NL68192.068.1 : 18-060 MEC Maastricht |