No registrations found.
ID
Source
Brief title
Health condition
Oral Squamous Cell Carcinoma (OSCC)
NL: Mondholtecarcinomen
Sponsors and support
Intervention
Outcome measures
Primary outcome
To compare mucosal shrinkage (from in vivo to histopathological examination) in each arm
Secondary outcome
- Shrinkage from in-vivo to directly after resection
- Shrinkage from in-vivo to after formalin fixation
- To define a shrink factor for each resection modality, taking into account the individual energy settings used.
Study objective
While head and neck surgeons aim for a 1 cm healthy tissue margin during resection of OSCC, pathological examination often reveals a smaller margin. Our hypothesis is that this occurs due to shrinkage of mucosa following the resection and due to the process of preparation for pathological examination, including formalin fixation, paraffin embedding,
Intervention
Resection using thulium laser or monopolar electric knife
Heidelberglaan 100
A.J. Pothen
Utrecht 3584 CX
The Netherlands
a.j.pothen@umcutrecht.nl
Heidelberglaan 100
A.J. Pothen
Utrecht 3584 CX
The Netherlands
a.j.pothen@umcutrecht.nl
Inclusion criteria
- >18 years old
- Confirmed OSCC stage I – IVa (Oncoline, 2004)
- ASA classification I and II
Exclusion criteria
- Previously operated/irradiated OSCC or other malignancy of the oral cavity.
- Stage IVb (inoperable disease)
- Co-morbidities resulting in disability to undergo surgery under general anesthesia
- Inability to sign informed consent
- impaired mental status
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4549 |
| NTR-old | NTR4692 |
| Other | : METC13-340 |