No registrations found.
ID
Source
Brief title
Health condition
Antibiotic resistance, Selective Decontamination of the Digestive tract (SDD), Selective Oropharyngeal Decontamination (SOD), Intensive Care Unit (ICU)
Sponsors and support
Postbus 9600, 2300 RC Leiden
The Netherlands
Postbus 9600, 2300 RC Leiden
The Netherlands
Intervention
Outcome measures
Primary outcome
Rectal colonization with any resistant aerobic Gram-negative bacteria at any time point within 10 days after ICU discharge.
Secondary outcome
N/A
Background summary
N/A
Study objective
Usage of SDD or SOD has been shown to reduce the incidence of ventilator associated pneumonia (VAP) and to improve patient survival.
SDD and SOD were shown not to increase resistance of bacteria colonizing the digestive tract. It can not be excluded that antibiotics in the faeces suppress the growth of resistant bacteria during SDD, and that those resistant strains may quickly re-emerge after discontinuation of SDD. The rate of re-colonization with resistant enteral bacterial flora after cessation of SDD or SOD is currently unknown.
To determine factors associated with emergence and persistence of pathogenic Gram-negative bacteria and to assess the rate of return of resistant enteral bacterial flora after treatment with SDD or SOD a follow-up study will be performed of rectal cultures of patients after discharge from the ICU at determined intervals.
Study design
Days 0, 3, 6 and 10 after discharge form the ICU.
Intervention
Rectal cultures after usage of either Selective Decontamination of the Digestive tract (SDD) or Selective Oropharyngeal Decontamination (SOD).
Leiden University Medical Center<br>
Postbus 9600
E.H.R. Essen, van
Leiden 2300 RC
The Netherlands
+31 (0)71 5268015
e.h.r.van_essen@lumc.nl
Leiden University Medical Center<br>
Postbus 9600
E.H.R. Essen, van
Leiden 2300 RC
The Netherlands
+31 (0)71 5268015
e.h.r.van_essen@lumc.nl
Inclusion criteria
All adult ICU patients treated with either SDD or SOD for more than 4 days (96hrs).
Exclusion criteria
1. Patients younger than 18 years of age;
2. Patients treated with enteral antibiotics other than SDD or SOD during ICU-stay.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3167 |
| NTR-old | NTR3311 |
| Other | CME LUMC : 10 V006 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |