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ID
Source
Brief title
Health condition
Not applicable
Sponsors and support
Intervention
Outcome measures
Primary outcome
Myofibrillar protein synthesis rates
Secondary outcome
Whole-body protein kinetics and metabolism, plasma metabolites (e.g. glucose and insulin), 1-13C-phenylalanine incorporation
Background summary
Exercise and protein intake are the main stimuli for muscle protein anabolism. Protein dose-response studies have shown that the ingestion of ~20-25 g protein maximizes muscle protein synthesis rates at rest and following exercise. However, these studies have only assessed the anabolic response over a relatively short 4 h period. However, little is known about the time course of the muscle protein synthetic response to the ingestion of a large amount of protein. We hypothesize that the ingestion of a large amount of protein (i.e 100 g) results in a prolonged muscle protein synthetic response as compared to a moderate amount of protein (i.e. 25 g) that is currently suggested to maximize the muscle protein synthetic response.
Study objective
The ingestion of a large amount of protein will results in a higher muscle protein synthetic response over a prolonged period when compared to the ingestion of a moderate amount of protein
Study design
Acute tracer study (12-h interventional period).
Intervention
0 g protein
25 g protein
100 g protein
Jorn Trommelen
043-3881617
jorn.trommelen@maastrichtuniversity.nl
Jorn Trommelen
043-3881617
jorn.trommelen@maastrichtuniversity.nl
Inclusion criteria
- Male
- Aged between 18-40 years
- Healthy
- 18.5 ≤ BMI 30 ≤ kg·m-2
Exclusion criteria
- Smoking
- Sports/exercise > 4 sessions/week
- Lactose intolerant or allergies to milk protein
- A history of neuromuscular problems
- Use of anticoagulation medication
- Recent (<9 months) participation in amino acid tracer (L-[ring-2H5-phenylalanine, L-[ring-2H2]-tyrosine, and [1-13C]-leucine infusion) studies
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription acne medications).
- Strict vegetarian (because of standardized Aviko meal)
- Injury or condition that would limit the participant from performing the resistance exercise.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL7700 |
| Other | METC MUMC : METC19-012 |