No registrations found.
ID
Source
Brief title
Health condition
Patients with pulmonary arterial hypertension (PAH)
Sponsors and support
Intervention
Outcome measures
Primary outcome
- The relation between the systolic slope of the deformation-area loop and the end-systolic pressure-volume relationship of the pressure volume curve.
- The relation between the slope of the diastolic part of the deformation-area loop during passive filling and the end-diastolic pressure-volume relationship of the pressure volume curve.
Secondary outcome
Other correlation between the characteristics of the deformation-area loop and the pressure-volume curve.
Background summary
Recent technical developments allow monitoring of strain and area using echocardiography. Using this information enables the production of an deformation-area loop. In this study we will investigate the relationship between the non-invasive deformation-area loop and the pressure-volume curve, during different loading conditions of the right ventricle
Study objective
Objective: The overall aim of this project is to correlate the characteristic changes of the deformation-area loop to the properties of the pressure-volume curve. We hypothesize that the systolic slope of the deformation-area loop relates to the end-systolic pressure-volume relationship of the pressure volume curve.
Study design
na
Intervention
To create the pressure-volume changes we will use a balloon-catheter to partially obstruct the venous return in the Vena Cava inferior.
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Inclusion criteria
- strong suspicion of PAH, WHO group 1, confirmed during right hearth catheterization.
- Over 18 years of age
- voluntary
Exclusion criteria
- cardiovascular diseases, other than PAH
- diabetes mellitus
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6789 |
| NTR-old | NTR6974 |
| Other | CMO regio Arnhem-Nijmegen : 2017-3460 |