No registrations found.
ID
Source
Brief title
Health condition
obesity, type 2 diabetes
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Insulin sensitivity (hyperinsulinemic euglycemic clamp)
2. Diencephalic SERT ( [123I]FP-CIT SPECT)
3. Brain 5-HT neurotransmission (pharmacological MRI (phMRI) using citalopram).
Secondary outcome
Motivation and impulse control
Abdominal and liver fat
Circulating hormones and substrates: blood drawing
Sleep duration
Resting energy expenditure
Sympathetic and parasympathetic activity
Feeding behaviour
Study objective
Consuming most calories at breakfast compared to at dinner leads to more suppression of appetite and craving and enhances insulin sensitivity.
Study design
before and after diet
Intervention
Subjects will reduce their daily caloric intake with 50% for 4 weeks. Subjects will be randomized into either a hypocaloric diet group where 15% of total kcal have to be consumed with breakfast, 35% kcal with lunch and 50% kcal with dinner or a hypocaloric diet group where 50% of kcal have to be consumed with breakfast, 35% kcal with lunch and 15% kcal with dinner.
Inclusion criteria
men
>50 y
BMI >30
fasting glucose > 5.6 and/or insulin > 74
Stable weight three months prior to study inclusion
Exclusion criteria
Use of any medication except for those related to treatment of components of the metabolic syndrome (excluding insulin, oral glucose lowering drugs, beta-blockers)
Any actual medical condition except for treated hypothyroidism and the metabolic syndrome
History of any psychiatric disorder
Shift work
Irregular sleep pattern
Intensive sports (>3/week)
Restrained eaters
History of eating disorders (anorexia, binge eating, bulimia)
Smoking, XTC, amphetamine or cocaine abuse
Alcohol abuse (>3/day)
Contraindication MRI
Lactose intolerance
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4822 |
| NTR-old | NTR5399 |
| Other | METC : 2014_200 |