No registrations found.
ID
Source
Brief title
Health condition
Hemodialysis; hemodialyse
amino acid loss; aminozuur verlies
high-flux membrane; high-flux membraan
Sponsors and support
Intervention
Outcome measures
Primary outcome
• Total amount of amino acids lost in the dialysate during a routine HD session in the MUMC+ in grams / session and grams / kg body weight
• Change in plasma amino acid concentration in μmol / L
Secondary outcome
• Dietary intake in calories and grams of protein per 24 hours of the outpatient population on chronic HD in the MUMC+
• Handgrip strength in kg
• Lean body mass and relative lean body mass in kg and %, respectively
Background summary
‘Chronic hemodialysis patients show declined muscle function, exercise performance and quality of life after hemodialysis treatment is necessary. The cause of this decline is suggested to be multifactorial. One of the most important catabolic stimuli present in chronic hemodialysis patients might be loss of nutrients in the dialysate. Amongst these nutrients, amino acids form the most important macronutrients, as these are essential for muscle maintenance. To date, studies which assessed the amount of amino acid loss during hemodialysis did so in fasted patients. However, this might not represent the amino acid loss during routine hemodialysis, during which most patients are allowed to eat and/or drink. Therefore, this study will assess the amino acid loss in chronic hemodialysis patients consuming their habitual diet.’
Study objective
We hypothesize that the amino acid loss in the dialysate during a routine HD session in the MUMC+ will be between 8-12 g/session, resulting in a significant decline in plasma free amino acid concentration.
Study design
Pre (t=0) and post (t=180 - 300) hemodialysis
Every 30 minutes of the hemodialysis procedure (t=30, t=60, t=90, t=120, t=150, t=180, t=210, t=240, t=270).
Intervention
N/A
School for Nutrition and Translational Research in Metabolism (NUTRIM)
Department of Human Biology & Movement Sciences
UNS 50, room H2.330
Maastricht
The Netherlands
+31 43 388 1509
f.hendriks@maastrichtuniversity.nl
School for Nutrition and Translational Research in Metabolism (NUTRIM)
Department of Human Biology & Movement Sciences
UNS 50, room H2.330
Maastricht
The Netherlands
+31 43 388 1509
f.hendriks@maastrichtuniversity.nl
Inclusion criteria
• Age over 18 years
• Glomerular filtration rate <15 ml/min/1.73m2
• Urine production <100 ml/day
• HD treatment 3 times per week for 3-5 hours per session
• Chronic HD at the MUMC+ for >6 months
Exclusion criteria
• One or more missed HD sessions in the last 4 weeks before participation
• Hospital admission in the last 12 weeks before participation
• Pregnancy
• Infections (infectious diseases, skin infection, infection of mucous membranes, etc.)
• Cognitive disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6906 |
| NTR-old | NTR7101 |
| Other | METC-17-4-071 : METC azM/UM |