No registrations found.
ID
Source
Brief title
Health condition
non-metastastatic esophageal cancer
niet uitgezaaid slokdarmkanker
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are differences in kinetic profile and/or genetic profile between patients with and without a pathologic complete response after chemo radiation.
Secondary outcome
The association of the created predictive profile and relapse/survival outcome parameters
Background summary
Single-centre study
Study objective
The objective of the MORE studies is to select and validate a biomarker profile predictive for the response to weekly paclitaxel and carboplatin chemotherapy concomitant with radiotherapy in patients with esophageal cancer.
In the MORE-1 pilot study candidate biomarkers are selected using a multimodal approach combining genomics (next generation sequencing) and proteonomics/kinomics (kinase activity profiling). The objective of the MORE-2 study is to validate the classifier that is developed in the MORE-1 study in patients treated with definitive chemo radiation (without surgery).
Study design
response after surgery en 2 year follow-up for diseasefree survival and overall survival
Intervention
Staging and treatment will be performed according to local and Dutch treatment guidelines. During the regular endoscopic ultrasonography (EUS) staging procedure 4 extra biopsies for biomarker testing will be taken from the primary esophageal tumor. One extra blood sample for genetic analyses purposes will be collected combined with a regular chemotherapy associated blood collection.
Inclusion criteria
All patients referred to MCL with pathologically proven carcinoma of the esophagus and without distant metastases will be asked to participate
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4821 |
| NTR-old | NTR5323 |
| CCMO | NL53633.099.15 |
| OMON | NL-OMON42549 |