No registrations found.
ID
Source
Brief title
Health condition
Esophageal cancer, Fluorescence, NIRF, ICG
Sponsors and support
Intervention
Outcome measures
Primary outcome
To explore the feasibility and added value of intra-operative NIRF imaging to assess gastric conduit perfusion in minimally invasive esophagectomy.
Secondary outcome
Indentify the increase in procedure time, post-operative anastomotic leakage, patient and tumor characteristics
Background summary
Anastomotic leakage after esophagectomy is an early post-operative complication and a major cause of morbidity and mortality. Impaired arterial bloodflow of the gastric conduit is thought to be the most important cause of anastomotic leakage. Better assessment of gastric conduit perfusion and identification of the ideal level of anastomosis is needed. A promosing technique to assess the gastric conduit perfusion intra-operatively is near-infrared fluorescence (NIRF) imaging after injection with indocyanine green (ICG).
Study objective
ICG can be used to assess the gastric conduit perfusion during esophagectomy
Study design
-
Intervention
Near-infrared fluorescence (NIRF) intra-operative imaging after administration of ICG
Inclusion criteria
• All patients eligible for minimally invasive esophagectomy for esophageal cancer, with gastric conduit reconstruction and intra-thoracic gastro-esophageal anastomosis
• Aged 18 years or older
• Providing informed consent
Exclusion criteria
• Known pregnancy or breastfeeding
• Known iodine, shellfish or ICG hypersensitivity
• Known hyper-thyroidism
• Known liver or renal insufficiency
• Unable to provide informed consent
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5852 |
| NTR-old | NTR6032 |
| CCMO | NL58179.091.16 |
| OMON | NL-OMON45919 |