No registrations found.
ID
Source
Brief title
Health condition
What are the source(s), or origin(s), mode(s) of transmission and determinants of acquisition of MRSA of Unknown Origin (MUO) found in persons without presently known risk factor for MRSA carriage as defined by the current National WIP guideline?
Sponsors and support
Intervention
Outcome measures
Primary outcome
Development of a new algorithm. Implementation of the new algorithm by the HCC’s and public health. Evaluation of the algorithm is done by comparing the rate of MRSA carriers characterized as belonging to one of the defined risk groups (including new ones), to the rate of MRSA defined as MUO. If this study identified significant risk groups and implementation of this knowledge is sufficient, the risk group rate will increase over time.
Secondary outcome
A found difference in characteristics (phenotype, profiling, genetics) for MUO (MRSA) strains.
Background summary
The Erasmus MC, department of Medical Microbiology
and Infectious diseases has teamed up with the Center of Infectious
Disease Control of the RIVM for a new research project. The research
project is about MRSA of Unknown Origin: MUO – Risk Assessment and
Adjustment of Risk Classification. The research team, under guidance of
M.C.Vos (ErasmusMC) and N. van de Sande (CIb/EPI), will try to sort out
what causes an alarming rise of MRSA-prevalence outside the healthcare
facilities, presumably due to unknown sources. This rise consists out of
carriers without known risk factors, who fall outside our described risk
categories in the WIP guideline. This could be a threat to our
successful Search&Destroy policy.
The aim of the research is to find an explanation for the presence of
MUO in people without known risk factors for MRSA carriage. If a reason
is found, this will result in adaptation of the current guidelines. This
study is financed by ZonMW (government).
Study objective
The current rise of CA-MRSA in the Netherlands is due to them all being MRSA of Unknown Origin (MUO). We do not know the risk factors yet of these. If we do, the CA-MRSA will drop.
Study design
No interim analysis needed/planned.
Intervention
None.
's-Gravendijkwal 230
Postbus 2040
W.S.N. Lekkerkerk
Erasmus MC
's-Gravendijkwal 230
Postbus 2040
Rotterdam 3000 CA
The Netherlands
+31 10 7033510
w.lekkerkerk@erasmusmc.nl
's-Gravendijkwal 230
Postbus 2040
W.S.N. Lekkerkerk
Erasmus MC
's-Gravendijkwal 230
Postbus 2040
Rotterdam 3000 CA
The Netherlands
+31 10 7033510
w.lekkerkerk@erasmusmc.nl
Inclusion criteria
MRSA send by the laboratory to the RIVM. Inclusion based on being a MUO by routine questionnaire.
Exclusion criteria
Case with (severely) incomplete background epidemiological data.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1924 |
| NTR-old | NTR2041 |
| Other | ZonMW / METC ErasmusMC : 50-50800-98-085 / MEC-2009-415 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |