No registrations found.
ID
Source
Brief title
Health condition
1. Panic disorder;
2. aged;
3. drug therapy;
4. cognitive therapy;
5. paroxetine.
(NLD: Paniekstoornis, ouderen, farmacotherapie, cognitieve gedragstherapie, paroxetine).
Sponsors and support
2. GGz Nijmegen, Outpatient Department for Anxiety Disorders, Nijmegen
PO Box 7049, 6503 GM Nijmegen, the Netherlands.
Glaxo SmithKline BV, PO Box 780, 3700 AT Zeist, the Netherlands.
Intervention
Outcome measures
Primary outcome
Self-report instruments for anxiety cogntions and phobic avoidance: scores on the Dutch adaptations of the Agoraphobic Cognitions Questionnaire (ACQ) and the Mobility Inventory avoidance scale (MI).
Secondary outcome
Self-report instruments for depression and general psychopathology. Depressive symptoms were assessed with the Dutch adaptation of the Beck Depression Inventory (BDI) and general psychopathology was assessed with the Dutch adaptation of the Symptom Checklist (SCL-90).
Background summary
N/A
Study objective
1. Both paroxetine and cognitive behavioural therapy (CBT) are effective in the treatment of late-life panic disorder;
2. Differences in efficacy between paroxetine and CBT are small.
Study design
Assessments were completed at:
1. Week 0;
2. Week 8;
3. Week 14;
4. Week 26.
Intervention
1. Treatment with paroxetine 20 mg 1dd2 during 14 weeks;
2. Cognitive behavioural therapy according to a treatment manual for panic disorder during 14 weekly sessions;
3. A waiting-list control condition of 14 weeks.
For both active treatments, paroxetine and CBT, follow-up period is 12 weeks.
PO Box 7049,
G.J. Hendriks
Nijmegen 6503 GM
The Netherlands
+31-24-3837820
ghendriks@ggznijmegen.nl
PO Box 7049,
G.J. Hendriks
Nijmegen 6503 GM
The Netherlands
+31-24-3837820
ghendriks@ggznijmegen.nl
Inclusion criteria
1. Panic disorder with/without agoraphobia (DSM-IV-criteria);
2. >60 years.
Exclusion criteria
1. The presence of severe psychiatric disorders (e.g. psychosis, major depression, bipolar disorder);
2. A severe somatic condition which would hinder appropriate application of CBT (e.g. severe cardiovascular disease);
3. A contraindication for prescribing paroxetine (e.g. co-occurring use of anti-coagulantia);
4. Current use of an antidepressant in an adequate dose;
5. Current and adequate psychological treatment;
6. Abuse or dependency of alcohol or psychoactive substances;
7. Dementia and a score of 23 or less on the Mini-Mental State Examination.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1110 |
| NTR-old | NTR1144 |
| Other | CCMO-Arnhem/Nijmegen : 9803-0063. |
| ISRCTN | ISRCTN wordt niet aangevraagd/retrospectief |