No registrations found.
ID
Source
Brief title
Health condition
Non Hodgkin Lymphoma; Positron Emission Tomography
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Maximal Standard Uptake Value (SUVmax), SUV mean and intraindividual variability
Secondary outcome
N/A
Background summary
A pilot study to investigate which PET tracer, FDG or FLT, is best suited for early PET diagnosis of transformation in patients with low grade NHL. Study design: a prospective observational study. Patient population: patients with newly diagnosed follicular lymphoma and patients with newly diagnosed histological transformation of follicular lymphoma.
Study objective
The survival of patients with histological transformation might be better as treatment is started when there is still limited disease. PET-scanning can be used to to diagnose the process of transformation early. But it is not clear yet, which tracer, FLT or FDG, is better in distinguishing indolent lymphoma from histological transformation.
Study design
- At entry
- After performing both PET-scans
Intervention
Patients will receive two PET-scans: one with FDG tracer and one with FLT tracer.
After the diagnosis and before performing both PET-scans, patients have not received any treatment. PET-scans will be performed minimally one day, maximally 7 days apart, in random order.
Department of Hematology <br> PK 2 BR 018 <br>P.O Box 7057
M.J. Wondergem
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4442604
m.wondergem@vumc.nl
Department of Hematology <br> PK 2 BR 018 <br>P.O Box 7057
M.J. Wondergem
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4442604
m.wondergem@vumc.nl
Inclusion criteria
1. Patients with newly diagnosed follicular lymphoma or newly diagnosed histological transformation of follicular lymphoma proven by histological examination.
2. Ann Arbor stage at diagnosis: II, III or IV.
3. At least one lesion > 2 cm diameter.
4. After the diagnosis and before performing both PET scans they have not received any treatment.
5. Ability to remain supine for 60 min. (PET)
6. Written informed consent.
Exclusion criteria
1. Uncontrolled diabetes mellitus.
2. Physical inability to access PET facilities.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1426 |
| NTR-old | NTR1487 |
| Other | METC VUmc : 2008/191 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |