No registrations found.
ID
Source
Health condition
rapid transfusion (snel transfusie), platelet function (platjes functie), heat application (wamrte aplicatie), pressure application (druk applicatie)
Sponsors and support
Intervention
Outcome measures
Primary outcome
In vitro platelet function measurement assessed by multiple impedance aggregometrie (MEA-Multiplate Multiple aggregometer Dynabyte Medical Munich, Germany)) and light transmission aggragometrie (LTA-platelet aggregometer PAR-4 Hart Biologicals Ltd Hartlepool, UK)). Both function tests will be performed before and after the test condition (see above).
Secondary outcome
microparticle content measured by ELISA (ZYMUPHEN, MP-activity kit, Aniara, Mason, Ohio, USA)
pH, glucose and lactate measured in the Chiron rapid lab 850 blood gas analyser (Siemens Healthcare Diagnostics, Breda, the Netherlands)
Background summary
In emergency clincical condition transfusion of blood products is frequently enhanced by applying pressure and warmth or the combination of both to increase the speed of tansfusion. However platelet concentrates are known to be the most fragile blood products which might might be disrupted in function by applying warmth, pressure or the combnination of both. Aim of the study is to investigate the functional status of platelet concentrates before and after applying pressure or warmth (37-39 degree Celsius) or the combination of both. The in vitro function will be assessed by aggregometrie (impedance and light transmission) and by surrogate parameters (microparticles, glucoes, pH and lactate).
Study objective
pressure, heat and the combination of both do not negatively influence platelet function.
Study design
before and after applying of the experimental conditions
Intervention
We mimick the rapid infusion of blood products in urgent situations where red packed cells are warmed and infusied under pressure by applying
1. pressure (150 mmHg)
2. heat (37-39 degree Celsius)
3. combination of both
on platelet concentrates through a mock system.
MUMC+
P.Debeyelaan 25
M.D. Lancé
Maastricht 6202 AZ
The Netherlands
marcus.lance@mumc.nl
MUMC+
P.Debeyelaan 25
M.D. Lancé
Maastricht 6202 AZ
The Netherlands
marcus.lance@mumc.nl
Inclusion criteria
10 platelet concentrates with the same age
Exclusion criteria
concentrate with different ages
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4046 |
| NTR-old | NTR4235 |
| Other | : METC 13-4-087 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |