No registrations found.
ID
Source
Brief title
Health condition
Subfertility
Sponsors and support
Intervention
Outcome measures
Primary outcome
Ongoing pregnancy rate.
Secondary outcome
1. Number of follicles;
2. Number of oocytes retrieved.
Background summary
A prospective, randomized, double blind, placebo controled trial. Patients under the age of 39 years undergoing regular IVF or ICSI treatment combined with low dose aspirin or placebo.
Study objective
By its pharmalogical action it is likely that aspirin improves ovarian perfusion, uterine perfusion and reduces endometrial restraint on the implanting embryo. Therefore the hypothesis of this study is that the use of low dose aspirin in IVF improves pregnancy rates.
Study design
N/A
Intervention
Patients undergo regular IVF/ICSI treatment combined with low dose aspirin or placebo.
P.G.A. Hompes
VU University Medical Center, Department of Reproductive Medicine
De Boelelaan 1117
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4444444
p.hompes@vumc.nl
P.G.A. Hompes
VU University Medical Center, Department of Reproductive Medicine
De Boelelaan 1117
Amsterdam 1007 MB
The Netherlands
+31 (0)20 4444444
p.hompes@vumc.nl
Inclusion criteria
1. Patients undergoing IVF or ICSI treatment;
2. Age <39 years;
3. Cycle day 3 FSH < 10 IU/L;
4. No contra indications against the use of low-dose aspirin.
Exclusion criteria
1. Systemic diseases;
2. Hypertension;
3. Previous allergic reaction to study medication;
4. Previous OHSS;
5. Untreated endocrinopathies;
6. Smoking > 5 cigarettes/day;
7. BMI > 28.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL554 |
| NTR-old | NTR610 |
| Other | : N/A |
| ISRCTN | ISRCTN97507474 |