No registrations found.
ID
Source
Brief title
Health condition
COVID-19
Sponsors and support
Intervention
Outcome measures
Primary outcome
-Prevalence of residual lung damage (per type) at 3 and 12 month
-Estimated percentage of lung parenchyma affected by various types of diffuse lung damage (e.g., ground glass, consolidation, perfusion abnormalities)
-Number of lung segments affected by focal lung damage (e.g., traction bronchiectasis, residual lung emboli)
-Predictors of pulmonary damage after acute COVID‐19
Secondary outcome
n.a.
Background summary
Included patients will undergo a CT angiography instead of routine chest imaging after 3 months to be able to assess all types of pulmonary damage, including perfusion abnormalities, and a low‐dose CT after 12 months to establish chronicity of pulmonary damage.
Study objective
The primary aim of this study is to determine types and prevalence of residual pulmonary damage after hospital admission for acute COVID‐19. In particular, we aim at determining the prevalence of clinically “silent” pulmonary perfusion abnormalities and establish the connection between current complaints and lung damage as well as the relation between clinical factors during hospitalization and residual lung damage. The ultimate goal is to find predictors, modifiable by treatment during or after the hospital stay, that affect long‐term outcome positively. With this study we aim at better understanding of the chronic phase of the disease and of how adverse outcomes might be prevented.
Study design
3 months and 12 months after acute COVID-19
Intervention
CT angiography at 3 months and chest CT low dose at 12 months after acute COVID-19 infection
Inclusion criteria
● Hospital admission for COVID‐19
● CT during admission with CO‐RADS >=3
● Informed consent
Exclusion criteria
● Age < 18
● Pregnancy
● Renal failure (MDRD < 30 ml/kg/1,73m^2)
● Allergic reaction to iodine containing intravenous contrast media
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8765 |
| Other | CMO Regio Arnhem-Nijmegen : 2020-6637 |