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ID
Source
Brief title
Health condition
Latent tuberculosis infection
Sponsors and support
Intervention
Outcome measures
Primary outcome
-The proportion of patients with any of various predefined lesions suggestive of old tuberculosis infection detected by ultra low dose CT and chest radiography.
Secondary outcome
- inter-observer variability for latent tuberculosis related lesions on ultra low dose CT as compared to CXR.
- correlation lesions with preventive treatment
Background summary
A (computed tomography) CT scan has superior sensitivity for old tuberculosis related lesions compared to chest radiography in individuals with latent tuberculosis infection (LTBI), but clinical application of the CT scan in the screening for LTBI is hampered by a high radiation dose. Recently introduced ultra low-dose CT (ULDCT) has much improved diagnostic quality compared to chest radiography but uses a radiation dose comparable to that of a chest radiography.
This study aims to evaluate the diagnostic value of ultra low dose CT for latent tuberculosis. Patients diagnosed with latent tuberculosis will undergo an ultra low dose CT scan as well as a chest radiograph. Subsequently, all images will be scored for LTBI-specific lesions by two thoracic radiologists, independently. Both radiologists are unaware of the TB status of the study patients. We hypothesize that ultra low dose CT has better accuracy for LBTI detection than chest radiography.
Study objective
We hypothesize that the ultra low dose CT reveals significantly more often lesions suggestive for past tuberculosis infection compared to chest radiography
Study design
single visit
Inclusion criteria
All patients diagnosed with latent tuberculosis infection based on a positive tuberculin skin test and/or interferon-gamma release assay
Exclusion criteria
-pregnancy; age < 18yo
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9085 |
| Other | METC Leiden Den Haag Delft : P20.036 |