No registrations found.
ID
Source
Brief title
Health condition
Atrial Fibrillation
Epicardial Mapping
Heat Shock Protein
Cardiac Surgery
Pulmonary Vein Isolation
Electrical Cardioversion
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main endpoint of the study is development or recurrence of AF, or completion of five year follow up period. We will test the correlation between HSP levels and development or recurrence of AF, and the correlation between degree of electropathology and development/recurrence of AF.
Secondary outcome
The relationship between the atrial conduction pattern as visualised by epicardial mapping and structural tissue characteristics will be tested.
Study objective
Patient with a low baseline HSP level are more likely to have atrial electropathology and to develop postprocedural atrial fibrillation.
Study design
T = 0: procedure
Follow up:
T = 1: 6 mo
T = 2: 12 mo
T = 3: 24 mo
T = 4: 36 mo
T = 5: 48 mo
T = 6: 60 mo
Intervention
In patients undergoing cardiac surgery:
- Epicardial mapping
- Biopsie atrial appendage
In patients undergoing pulmonary vein isolation:
- Endovascular mapping
In all patients: bloodsamples for HSP determination
N.M.S. Groot, de
Erasmus MC, afdeling Cardiologie, Kamer BA-579
Rotterdam 3015 CE
The Netherlands
+31 (0)10 7034479
n.m.s.degroot@erasmusmc.nl
N.M.S. Groot, de
Erasmus MC, afdeling Cardiologie, Kamer BA-579
Rotterdam 3015 CE
The Netherlands
+31 (0)10 7034479
n.m.s.degroot@erasmusmc.nl
Inclusion criteria
Adult (>18 yr) patients undergoing elective cardiac surgery, pulmonary vein isolation or electric cardioversion
Exclusion criteria
Paced Atrial Rhythms
Hemodynamic Instability
Presence of Assist Devices
Usage of Inotropic Agents
Emergency Cardiac Surgery
Redo Cardiac Surgery
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4524 |
| NTR-old | NTR4658 |
| CCMO | NL49785.078.14 |
| OMON | NL-OMON53108 |