The induction of necrosis after reduced RT dose.
ID
Source
Brief title
Health condition
radiotherapy, myxoid liposarcoma, soft tissue sarcoma (radiotherapie, myxoid sarcomm en weke delen sarcoom)
Sponsors and support
Intervention
Outcome measures
Primary outcome
The dose reduction will be regarded as a success if at least 90% of thus treated patients show at least 90% necrosis in the definitive resection specimen.
Secondary outcome
The aim is to provide a stopping rule for inefficacy of the new dose.
Background summary
To study whether a dose reduction of preoperative radiotherapy in MLS from 50Gy to 36Gy is equally effective in inducing extensive necrosis (thus maintaining comparable clinicopathological responses).
Study objective
The induction of necrosis after reduced RT dose.
Study design
1. Start inclusion 01-Jan-2011;
2. Finish 01-Jul-2012.
Intervention
To study whether a dose reduction of preoperative radiotherapy in MLS from 50Gy to 36Gy is equally effective in inducing extensive necrosis (thus maintaining comparable clinicopathological responses).
Inclusion criteria
1. Age >18 years;
2. By biopsy proven myxoid sarcoma;
3. Performance score ECOG 0-2.
Exclusion criteria
1. Prior radiotherapy to target area;
2. Anticoagulant medication of any kind; especially Ascal (and derivates), coumarines, all heparin and heparin-like formulations;
3. Pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2472 |
| NTR-old | NTR2588 |
| Other | : N10DMY |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| CCMO | NL33144.031.10 |
| OMON | NL-OMON47519 |