No registrations found.
ID
Source
Health condition
Bestuderen van de bloeddoorstroming van de hersenen in reactie op een hoog calorische stimulus.
To study cerebral blood flow with 1Tesla MRI before and after ingestion of a liquid meal.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Percentage and/or absolute changes in local cerebral blood flow after a liquid meal.
Secondary outcome
1. Difference in cerebral blood flow between males and females;
2. Influence of ingestion of a liquid meal.
Background summary
The brain is the master regulator of food intake. It has been shown that there are anatomical differences between certain brain areas in obese compared with lean people. Also, the response to food related ques seems to be different between these groups. The latter can be studied by measuring cerebral blood flow with fMRI.
Study objective
The response in cerebral blood flow upon ingestion of a liquid meal differs between males and females.
Study design
One measurement (fMRI).
Intervention
Ingestion of a high-caloric liquid meal.
Department of Endocrinology and Metabolism <br>
P.O. Box 22660<br> 1100 DD
B.A.M. Weijer, de
Meibergdreef 9 (F5-177)
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666849
B.A.deWeijer@amc.uva.nl
Department of Endocrinology and Metabolism <br>
P.O. Box 22660<br> 1100 DD
B.A.M. Weijer, de
Meibergdreef 9 (F5-177)
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666849
B.A.deWeijer@amc.uva.nl
Inclusion criteria
1. 15 lean male subjects/ 15 lean female subjects;
2. BMI 20- 25 kg/m²;
3. Age 18 – 60 years;
4. Stable weight 3 months prior to study inclusion;
5. Caucasian;
6. Written informed consent;
7. Right handed.
Exclusion criteria
1. Claustrophobia;
2. Metal objects in the body (e.g. pacemaker);
3. Left handed;
4. Smoking and/or Alcohol/Drug abuse;
5. Intensive exercise (more than 3 times per week);
6. Eating disorder (other DSM IV diagnosis);
7. Medication use that interferes with dopamine metabolism or nutrient absorption;
8. DM.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2194 |
| NTR-old | NTR2318 |
| Other | METC AMC : 09/248 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |