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ID
Source
Brief title
Health condition
not applicable, mostly healthy individuals
Sponsors and support
Intervention
Outcome measures
Primary outcome
Leiden Surgical rating score
Secondary outcome
Hemodynamic conditions
Postoperative recovery and pain
Peroperative NOL values
Background summary
To assess whether a deep neuromuscular block provides better surgical conditions (L-SRS) than a moderately deep block as derived from a surgical rating score during sevoflurane anesthesia.
Study objective
The difference in surgical conditions between deep or moderate neuromuscular block is absent during sevoflurane anesthesia
Study design
N.A.
Intervention
deep neuromusculair block vs moderate neuromusculair block
Inclusion criteria
(i) Patients that will undergo an elective laparoscopic (donor) nephrectomy;
(ii) ASA class I-III
(iii) > 18 years of age;
(iv) Ability to give oral and written informed consent.
Exclusion criteria
(i) Known or suspected neuromuscular disorders impairing neuromuscular function;
(ii) Allergies to muscle relaxants, anesthetics or narcotics;
(iii) A (family) history of malignant hyperthermia;
(iv) Women who are or may be pregnant or are currently breast feeding;
(v) Renal insufficiency, as defined by serum creatinine x 2 of normal, or urine output < 0.5 ml/kg/h for at least 6 h. When available, other indices will be taken into account as well such as glomerular filtration rate < 60 ml/h and proteinuria (a ratio of 30 mg albumin to 1 g of creatinine).
(vi) Previous retroperitoneal surgery at the site of the current surgery.
(vii) Body mass index > 35 kg/m2
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7844 |
| Other | METC LUMC : P17.049 |