No registrations found.
ID
Source
Brief title
Health condition
Chronic obstructive pulmonary disease
Chronisch obstructief longlijden, chronische bronchitis, longemfyseem
Sponsors and support
Intervention
Outcome measures
Primary outcome
Systemic inflammatory response.
Secondary outcome
None.
Background summary
The effect of non-invasive ventilation during exercise on systemic inflammatory responses will be investigated in a double blind randomized placebo controlled (sham ventilation) cross-over design. During the first visit patients will cycle as long as possible, but maximally 20 minutes and during the second visit they will be asked to cycle exactly as long as during the first visit (isotime). Blood will be obtained at rest, at the end of the activity and 30 minutes afterwards to investigate markers of systemic inflammation.
Study objective
Non-invasive ventilation reduces the inflammatory response to exercise.
Study design
1. Rest;
2. After exercise;
3. 30 minutes after exercise.
Intervention
Non-invasive ventilation & sham ventilation.
Radboud University Nijmegen Medical Centre
PO Box 9101
JDC Hannink
Department of Pulmonary Diseases
Radboud University Nijmegen Medical Centre
PO Box 9101
Nijmegen 6500 HB
The Netherlands
+31 (0)24-6859580
J.Hannink@LONG.umcn.nl
Radboud University Nijmegen Medical Centre
PO Box 9101
JDC Hannink
Department of Pulmonary Diseases
Radboud University Nijmegen Medical Centre
PO Box 9101
Nijmegen 6500 HB
The Netherlands
+31 (0)24-6859580
J.Hannink@LONG.umcn.nl
Inclusion criteria
COPD patients.
Exclusion criteria
1. Long term oxygen therapy;
2. Respiratory insufficiency;
3. Asthma;
4. Exercise limiting disorders;
5. Exacerbation in last 6 weeks;
6. Smoking;
7. Oral corticosteroids;
8. Chronic inflammatory disorders.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1877 |
| NTR-old | NTR1991 |
| Other | METC Radboud University Nijmegen : 2008/125 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |