No registrations found.
ID
Source
Brief title
Health condition
Cystic Fibrosis (CF)
Sponsors and support
Intervention
Outcome measures
Primary outcome
Opacification of sinuses on CT-scan (Lund-Mackay score)
Secondary outcome
- Development of paranasasl sinuses
- Severity of CF
- Onset of sinonasa pathology
- Symptoms of sinonasal disease
- Outcome of nasopharyngeal swab
- Anatomic variations in sinonasal area
- Outcome of lower airway culture
Background summary
Adult CF patients often display signs of chronic rhinosinusitis on a CT-scan. However, to date the onset and the pathogenesis of this sinonasal pathology in Cystic Fibrosis in unclear. By studying children with CF from birth untill 18 years, more knowledge on the onset of sinonasal disease can be gathered. More knowledge on the pathogenesis of sinonasal disease is necessary to develop an accurate treatment protocol for this pathology. Early interventions may prevent a chronic course of sinonasal pathology and eventually less complaints in adult life.
Study objective
N/A
Study design
Study procedures performed in one day
Intervention
Observational study:
- CT-sinus
- Nasopharyngeal swab
- Lower airway culture
Maaike Berkhout
Den Haag 2504 LN
The Netherlands
+31 (0)70 2102076
M.Berkhout@hagaziekenhuis.nl
Maaike Berkhout
Den Haag 2504 LN
The Netherlands
+31 (0)70 2102076
M.Berkhout@hagaziekenhuis.nl
Inclusion criteria
- Confirmed diagnosis of Cystic Fibrosis based on genotyping or a positive sweat test
- Age 0-<18 years
Exclusion criteria
- Gross inmmunodeficiency (congenital or acquired)
- Congenital mucociliary problems other than CF (e.g. Primary Ciliairy Diskinesia)
- ASA syndome (Samter's trias; nasal polyps, asthma and aspirin sensitivity)
- Intranasal neoplasia
- Systemic vasculitis and granulomatous diseases (e.g. M. Wegener, sarcoidosis, Churg-Strauss syndrome)
- Recently (within 1 month) CT-sinus performed
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3989 |
| NTR-old | NTR4161 |
| CCMO | NL43794.098.13 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON38689 |