No registrations found.
ID
Source
Brief title
Health condition
Obesity
Surgery induced weight loss
Osteoporosis
Sponsors and support
Intervention
Outcome measures
Primary outcome
* Vertebral bone marrow fat fraction measured by QSCI
* Vertebral bone mineral density measured by QCT
Secondary outcome
Bone turnover markers (CTx, P1NP, osteocalcin), 25-hydroxy vitamin D, parathyroid hormone, calcium, albumin, phosphate, alkaline phosphatase, creatinin, complete blood count (CBC), reticulocytes, leptin, adiponectin
Background summary
Bone marrow fat and bone mineral density are inversely correlated. Greater bone marrow fat is also associated with fractures. Bone marrow fat is regulated differently from visceral and subcutaneous fat. In rodents, caloric restriction results in high bone marrow fat. However, little studies have been published that examined the effects of weight loss on bone marrow fat in humans.
Study objective
Energy restriction by bariatric surgery in obese women increases bone marrow fat and decreases bone mass.
Study design
* 3 months and 2 weeks pre-operative
* 3 and 12 months post-operative
Intervention
Roux-en-Y gastric bypass
P.H.L.T. Bisschop
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666071
p.h.bisschop@amc.uva.nl
P.H.L.T. Bisschop
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666071
p.h.bisschop@amc.uva.nl
Inclusion criteria
* Female sex
* Age: 18-55 years50 years and older
* Postmenopausal
* Scheduled for Roux-en-Y gastric bypass
* Able to fit on MRI table
Exclusion criteria
* Contraindications to MRI scanning
* Use of bone-modifying or adipose tissue-modifying drugs
* Bone / bone marrow diseases
* Diseases or medication known to have an effect on bone marrow fat
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4951 |
| NTR-old | NTR5056 |
| CCMO | NL51696.018.14 |
| OMON | NL-OMON43737 |