No registrations found.
ID
Source
Health condition
colorectal cancer, interval colorectal cancer colonoscopy, adenomas, polyps, cause, incidence
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Prevalence of interval CRCs in a Dutch population;
2. Clinical characteristics;
3. Molecular characteristics;
4. Differences with non-interval CRCs.
Secondary outcome
N/A
Background summary
In routine practice, interval colorectal cancers (cancers that develop after a colonoscopy) are more common than previously expected. Variations between endoscopists with regard to detection and effective treatment of precursor lesions, as well as differences in biology are critical factors, yet their precise contribution remains unclear. In view of the forthcoming screening for colorectal cancers (CRCs) in the Netherlands, this issue is timely as it may permit to design more effective CRC preventive strategies and provide new insights into the pathogenesis of CRC.
Study objective
What are the causes of interval colorectal cancers? Are they the result of technology related or biology related factors?
1. Interval colorectal cancers (CRCs) are more common than expected;
2. Interval CRCs are characterized by a different macroscopic appearance, rendering them more likely to be missed in routine colonoscopy;
3. Precursor lesions of interval CRCs have different molecular features which are associated with an increased risk for rapid progression to CRC.
Study design
N/A
Intervention
None: "niet WMO-plichtig onderzoek".
Retrospective analysis of clinical and pathology records, and molecular analysis on resection specimen.
Maastricht University Medical Center<br>
Postbus 5800
C. Clercq, le
Maastricht 6202 AZ
The Netherlands
+31 (0)43 3875021
chantal.le.clercq@mumc.nl
Maastricht University Medical Center<br>
Postbus 5800
C. Clercq, le
Maastricht 6202 AZ
The Netherlands
+31 (0)43 3875021
chantal.le.clercq@mumc.nl
Inclusion criteria
All patients diagnosed with colorectal cancer between January 2001 and December 2010 in the South of Limburg: Maastricht University Medical Center, Atrium Medical Center Heerlen, Orbis Medical Center Sittard.
Exclusion criteria
Patients with inflammatory bowel disease or known hereditary polyposis syndromes.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2946 |
| NTR-old | NTR3093 |
| Other | METC MUMC / METC Atrium MC Heerlen : 10-4-061.4/pl / 11-N-79; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |