No registrations found.
ID
Source
Brief title
Health condition
Tetralogy of Fallot (tetralogie van Fallot), pulomnary valve replacement (pulmonaalklepvervanging) ventricular dyssynchrony (ventrikel dyssynchronie)
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcome: Differences in time to peak systolic velocity between different segments of the right ventricle:
- Right ventricular outflow tract
- Right ventricular free wall
- Right ventricular septum.
The greatest difference in time to peak systolic velocity of the segments (latest peak systolic velocity minus earliest peak systolic velocity) will be used as a measure of dyssynchrony, and this value will be compared before and after PVR
Secondary outcome
Effect of PVR on ventricular function
(eg. volume, diastolic function, E/A ratio, pulmonary regurgitation, Vo2 max, clinical condition)
Background summary
Prospective study to evaluate the effect of pulmonary valve replacement on mechanical ventricular dyssynchrony in young corrected tetralogy of Fallot patients
Study objective
Improvement of the RV function by pulmonary valve replacement will result in improvement of RV dyssynchrony in corrected tetralogy of Fallot patients
Study design
- approximately 3-6 months before PVR
- approximately 3-6 months after PVR
Intervention
Group: patients with corrected Tetralogy of Fallot who undergo pulmonary valve replacement.
Intervention: pulmonary valve replacement (PVR), surgical or percutaneous
Willem Alexander Kinder- en Jeugdcentrum<br>
Peadiatric Cardiology<br>
P.O. box 9600<br>
A.E. Hulst, van der
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5261593
a.e.van_der_hulst@lumc.nl
Willem Alexander Kinder- en Jeugdcentrum<br>
Peadiatric Cardiology<br>
P.O. box 9600<br>
A.E. Hulst, van der
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5261593
a.e.van_der_hulst@lumc.nl
Inclusion criteria
1. Corrected tetralogy of fallot
2. >8 year
3. Scheduled for pulmonary valve replacement
Exclusion criteria
1. Claustrophobia
2. Renal disease
3. Cardiac arrythmia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1329 |
| NTR-old | NTR1388 |
| Other | METC LUMC : p08.023 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |