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ID
Source
Brief title
Health condition
Not applicable
Sponsors and support
Intervention
Outcome measures
Primary outcome
VAS for itch.
Secondary outcome
Size of flare, character and constancy of itch.
Background summary
Electrical neuromodulation therapies such as transcutaneous electrical nerve stimulation (TENS), spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS) have earned their place in the treatment of neuropathic pain and are commonly used as a last resort treatment for neuropathic pain. Though it is known that pain and itch are neurologically related phenomena, electrical neuromodulation is far less used in the treatment of itch. Nonetheless, there is evidence that modes of electrical neuromodulation such as TENS are useful in the treatment of itch. We therefore aim to determine whether SCS and/or DRGS can influence the perception of experimentally induced itch.
Study objective
SCS and/or DRGS alleviates histamine induced itch.
Study design
Baseline, 15 minutes after histamine application and 1, 5, 10, 15, and 30 minutes after switching on SCS or DRGS.
Intervention
Percutaneous administration of a drop of histamine solution to an area innervated by the SCS or DRGS and simultaneous administration of a drop of histamine solution to an area not innervated by the SCS or DRGS.
Inclusion criteria
Good effect of SCS or DRGS; the area innervated by the SCS or DRGS must extend to a healthy, pain free area of skin; participants must not have objections against switching off his or her SCS or DRGS for up to one hour; age >= 18 years; no ongoing itch perception.
Exclusion criteria
Generalized skin disorder; systemic disease associated with pruritus; complex regional pain syndrome; allergy or hypersensitivity; contra-indications for histamine administration; use of opioids; use of drugs that might potentially prevent the development of a flare.
Design
Recruitment
IPD sharing statement
Plan description
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8591 |
| Other | METC Erasmus MC : MEC-2020-0241 |