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ID
Source
Brief title
Health condition
blood flow restriction, resistance exercise, muscle protein synthetic rate
Sponsors and support
Intervention
Outcome measures
Primary outcome
Muscle protein synthesis (MPS) rate
Secondary outcome
The early (0-2h) and late (2-5h) muscle protein synthesis rates
Background summary
The combined application of blood flow restriction and low load resistance exercise has been found to stimulate muscle protein synthetic rate to a similar extent as the traditional high load resistance exercise without blood flow restriction. However, it is still unclear whether blood flow restriction alone (without exercise) is a strong enough stimulus to significantly increase muscle protein synthesis.
The main aim of the current study will be to assess the effect of acute blood flow restriction and blood flow restriction combined with resistance exercise on the muscle protein synthetic rate in healthy young male subjects
Study design
The early (0-2h), late (2-5h) and total (0-5h) muscle protein synthesis
Intervention
Blood flow restriction of lower extremity with or without low load resistance exercise
J. Nyakayiru
Maastricht University Medical Centre+ P.O. Box 616
Maastricht 6200 MD
The Netherlands
+31 43 388 1617
Jean.nyakayiru@maastrichtuniversity.nl
J. Nyakayiru
Maastricht University Medical Centre+ P.O. Box 616
Maastricht 6200 MD
The Netherlands
+31 43 388 1617
Jean.nyakayiru@maastrichtuniversity.nl
Inclusion criteria
-Males - Aged between 18-35 years - Healthy - 18.5≤BMI ≤30 kg/m2
Exclusion criteria
- Smoking - Resistance exercise >1 session/week - Sports/exercise >3 session/week - Lactose intolerant - A history of neuromuscular problems - Recent (<1 y) participation in amino acid tracer studies - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription acne medications).
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5727 |
| NTR-old | NTR5914 |
| CCMO | NL56003.068.15 |
| OMON | NL-OMON43514 |