No registrations found.
ID
Source
Brief title
Health condition
Diabetes Mellitus type II (DMII)
insulin resistance/ insuline resistentie
Sponsors and support
Intervention
Outcome measures
Primary outcome
Endogenous glucose production.
Secondary outcome
1. Peripheral insulin sensitivity;
2. Lympathetic activity;
3. Glucoregulatory hormones.
Background summary
It has been hypothesized that dopamine may be involved in the modulation of glucose metabolism. This hypothesis is partly based on the observation of the relationship between schizophrenia and diabetes and the finding that lean drug-naive schizophrenic patients display hepatic insulin resistance.
We will investigate glucose metabolism in healthy subjects after dopamine depletion with AMPT and placebo, using a hyperinsulinemic euglycemic clamp with stable isotopes.
Study objective
Hepatic insulin sensitivity increase after dopamine depletion, with a-methylparatyrosine (AMPT).
Study design
We will draw bloodsamples in the basal state, after de first and after the second step of the clamp.
Intervention
Each subject will be studied twice. Once after dopamine depletion (with AMPT) and once after placebo. We will perform a 2-step hyperinsulinemic euglycemic clamp, using stable isotopes.
Department of Endocrinology & Metabolism<br>
F5-162
N.M. Lammers
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662663
N.M.Lammers@amc.uva.nl
Department of Endocrinology & Metabolism<br>
F5-162
N.M. Lammers
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5662663
N.M.Lammers@amc.uva.nl
Inclusion criteria
1. Healthy men;
2. Age: 18-35 years;
3. BMI: 20-25 kg/m2.
Exclusion criteria
1. DM type I and II or any other chronic disease;
2. Renal insufficiency or elevated liver enzymes;
3. Family history of DMII;
4. Primary dyslipidemia;
5. Use of any drugs and history of drug abuse;
6. Alcohol consumption >3/day;
7. Performance of vigorous exercise;
8. History of psychiatric disorders.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL1885 |
| NTR-old | NTR1999 |
| Other | METC Academic medical center : MEC 08/347 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |