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ID
Source
Brief title
Health condition
fertility problems
ongewenste kinderloosheid
Sponsors and support
Heerenveenseweg 99b
8471 ZA Wolvega
Netherlands
Intervention
Outcome measures
Primary outcome
association between cytokine profile and subfertility
association between vaginal microbiome and subfertility
are cytokine profiles related to vaginal microbiome patterns?
Secondary outcome
Statisitical model to predict which patient variables can be used to quantify the prognosis of subfertility.
Background summary
In 20 normal fertile and 20 subfertile women visiting Nij Barrahus, fertility center a bloodsample and a vaginal swab will be taken at one specific moment in their treatment cycle (moment of IUI, scheduled 24-30H after a spontaneous LH surge).
Does cytokine and/or vaginal microbiome determinations reflect a specific profile, which can be attributed to a (low) chronic state of inflammation and therefore to a changed innate immune system?
Study objective
Hypothesis: Subfertility is influenced by (low) chronic inflammation. Cytokine and microbiome profiling can be substantial in detecting the state of chronic inflammation and may thus help in solving subfertility.
Study design
Recruitment will end April 2016.
Intervention
none
Research subjects are treated with IUI (IntraUterine Insemination). After informed consent one time bloodsampling + one vaginal swab will be taken for determinations of respectively cytokines and microbiome profiling.
J.P.W. Vermeiden
Heerenveenseweg 99b
[default] 8471 ZA
The Netherlands
Tel. 0561610030 Of 0646161592
j.vermeiden@xs4all.nl
J.P.W. Vermeiden
Heerenveenseweg 99b
[default] 8471 ZA
The Netherlands
Tel. 0561610030 Of 0646161592
j.vermeiden@xs4all.nl
Inclusion criteria
women with idiopathatic subfertility for a duration of 3 years and more (N=20)
lesbian couple and single mothers seeking to fulfill their childwish, with negative histories of cycle irregularity, STD's,, abdominal surgery. (N=20)
Exclusion criteria
1. free of fever during the past month prior to study entry
2. free of antimicrobial interventions during the past month of study entry
3. positive CAT IgG sampling
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5286 |
| NTR-old | NTR5393 |
| Other | : |