No registrations found.
ID
Source
Health condition
childhood obesity obesitas in kinderen
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Neural activation (percentage signal change) in response to viewing pictures healthy and unhealthy foods.
2. Neural activation (percentage signal change) in response to (un)healthy food choice.
Secondary outcome
1. Scores on the liking of the food images and their perceived healthiness
2. Scores on the neuropsychological measures (DDT, WCST, SST and IGT or HDT).
Background summary
N/A
Study objective
We hypothesize that during the viewing of unhealthy vs. healthy food pictures children will show more activity in areas related to food motivation (striatum, OFC, hippocampus). Likewise, we expect subjects with an unhealthy diet to show more activation than subjects with a healthy diet in these areas. In contrast, during food choice we expect an interaction effect of children vs. adults and unhealthy vs. healthy eaters in areas related to inhibition, such as the anterior cingulate gyrus. Unhealthy eating adults are hypothesized to have less inhibitory control than healthy eating adults, and are therefore expected to show more activation in this area to come to the same result. Children however, are expected to show less activation in this area during inhibition, because the function of the area has not been fully developed yet.
Study design
There are two moments of measurement, 3-7 days a part. On the first moment of contact neuropsychological measurements and questionnaires will be obtained, on the second moment the fMRI scan will be made.
Intervention
Since this is an observational study there are no interventions as a part of the study design. The neural correlates of food choice and food viewing will be examined in two groups of children (healthy weight and overweight) and their same-sexed parent.
Division of Human Nutrition
Bomenweg 2
Biotechnion (307), room 323
Wageningen 6703 HD
The Netherlands
0317 – 484681
Paul.Smeets@wur.nl
Division of Human Nutrition
Bomenweg 2
Biotechnion (307), room 323
Wageningen 6703 HD
The Netherlands
0317 – 484681
Paul.Smeets@wur.nl
Inclusion criteria
Healthy
Children: age 10-13 y
Children: age-corrected BMI between 20 and 25 kg/m2 or 27.5-35 kg/m2
Parents: age 28-48 y
Parents: BMI between 20 and 35 kg/m2
Exclusion criteria
Left handed
Presence of metal in the body incompatible with MRI scanning
Smoking
Having a special diet (e.g. to lose weight, medically prescribed diet in the past 6
months, no meat etc.)
Highly restrained eating.
Having a food allergy
Alcoholconsumption > 28 units/week
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL4110 |
NTR-old | NTR4255 |
Other | ABR NL43992.041.13 : METC UMCU 13-200 |
ISRCTN | ISRCTN wordt niet meer aangevraagd. |