No registrations found.
ID
Source
Brief title
Health condition
Psychiatric illness; ADHD; depression; schizophrenia; cognitive abilities; attention; executive functions; reward learning
Sponsors and support
Intervention
Outcome measures
Primary outcome
Performance on neuropsychological tests and associated brain activity (MRI)
Secondary outcome
Reaction-speed and performance (% correct) at several focus and learning tasks.
Study objective
In comparison to placebo (PLC), atomoxetine (ATX) alters specific components of brain networks underlying cognition and reward-related networks and modulates task performance.
Study design
3 timepoints. Session 1 (Day 1), Session 2 (Day 4), session 3 (Day 11).
Intervention
The study consists of three sessions.
Session 1: In a 1-hour session, we will measure mood variables and executive functions.
Session 2 and 3:We will measure attention-related skills and related brain activity with neuropsychological tasks and MRI. On one occasion, the participant receives a placebo (a fake pill) and on the other occasion atomoxetine 60mg (oral; a safe challenge that temporarily increases noradrenaline and dopamine in the brain).
Dennis Hernaus
Vijverdalseweg 1 (2e verdieping SN gebouw)
Maastricht 6226NB
The Netherlands
T +31 43 388 3896
strax@maastrichtuniversity.nl
Dennis Hernaus
Vijverdalseweg 1 (2e verdieping SN gebouw)
Maastricht 6226NB
The Netherlands
T +31 43 388 3896
strax@maastrichtuniversity.nl
Inclusion criteria
- Male gender
- Age between 18 and 30
- Right-handed
Exclusion criteria
- Psychiatric disorders
- Neurological disorders
- Endocrine disorders
- Drug or alcohol dependence
- Current (recreational) drug use; will be checked in urine
- Recent use of corticosteroids
- Past/current psychopharmacological treatment (e.g. antidepressants, antipsychotics, mood stabilisers, sleeping medication)
- High (>28) or low (<18) Body-Mass Index
- Contraindication for a magnetic resonance imaging (MRI) scan
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5558 |
| NTR-old | NTR5679 |
| CCMO | NL53913.068.15 |
| OMON | NL-OMON43560 |