No registrations found.
ID
Source
Health condition
Pathologic complete response, prediction, rectal cancer, machine learning, chemoradiotherapy, PET
Sponsors and support
Dr.Tanslaan 12
6229 ET Maastricht
Dr.Tanslaan 12
6229 ET Maastricht
Intervention
Outcome measures
Primary outcome
Pathologic complete response, defined by ypT0N0 stage extracted from pathologic reports.
Secondary outcome
1. Local control;
2. Distant metastases;
3. Survival;
4. Relapse free survival;
5. Metastases free survival.
Background summary
Accurate prediction of pathologic complete response can help in the selection of patients for optimized treatment, sphincter-preserving surgery, less extensive resection, planning of extra radiation boosts, or even delayed surgery with a wait-and-see policy. Therefore it is valuable to develop an accurate, data-driven model to predict pathologic complete response for rectal cancer patients in order to individualize treatment. CTPET-imaging is known to have predictive value for response in rectal cancer from univariate analyses. In this study CTPET imaging is combined with clinical prognostic factors to develop models and corresponding nomograms to predict response sufficiently accurate to use in trials and in the clinic.
Study objective
A model based on the combination of clinical prognostic factors and features extracted from tumor contours from CTPET has a high accuracy to predict pathologic complete response after chemoradiotherapy in locally advanced rectal cancer.
Study design
N/A
Intervention
1. FDG-PET imaging (pretreatment);
2. Blood sampling (facultative);
3. FDG-PET imaging (posttreatment, facultative).
Ruud Stiphout, van
Maastricht 6229 ET
The Netherlands
+31 (0)88 4455666
ruud.vanstiphout@maastro.nl
Ruud Stiphout, van
Maastricht 6229 ET
The Netherlands
+31 (0)88 4455666
ruud.vanstiphout@maastro.nl
Inclusion criteria
1. Histological proven rectal cancer;
2. Only primary tumors; no recurrences;
3. Only concurrent chemoradiotherapy treatment;
4. 18 years or older.
Exclusion criteria
1. No adenocarcinoma histology;
2. History of prior pelvis radiotherapy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2049 |
| NTR-old | NTR2166 |
| Other | : |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |