No registrations found.
ID
Source
Health condition
VIM-2 positive Pseudomonas aeruginosa
Healthcare-related/Gezondheidszorg gerelateerd
Multi-drug resistant/multiresistent
Risk factors/Risicofactoren
Sponsors and support
Intervention
Outcome measures
Primary outcome
VIM-2 positive culture of P. auruginosa (infection or colonization)
Absence of VIM-2 positive P. auruginosa (infection or colonization)/culture of P. auruginosa (infection or colonization)
Secondary outcome
Not appliacble
Background summary
Rationale: Since continuous outbreaks of VIM-2 positive P. aeruginosa occur in the Erasmus MC, additional research is needed to expand our knowledge of VIM-2 positive P. aeruginosa transmission and to identify risk factors applicable to the Erasmus MC, so we can implement targeted prevention strategies in order to stop the outbreaks.
Objective: The main aim of this study is to analyze the risk-factors associated with acquiring VIM-2 positive P. aeruginosa, among patients admitted to the Erasmus University Medical Center since the first recorded case in 2003. The secondary aim is to investigate whether there is a difference in risk-factors between ICU and non-ICU patients in the Erasmus Medical Center. Also, to investigate whether Diversilab types are associated with specific risk-factors.
Study design: Case-control study (observational)
Study population: The population consist of adult patients (>=18years) admitted to the Erasmus MC
Main study parameters/endpoints: The main outcomes are: VIM-2 positive culture after 48 hours after admittance in the Erasmus MC (Colonization and infection) and VIM-2 negative colonization and infection
Study objective
The aim of this study is to analyze the risk-factors associated with acquiring VIM-2 positive P. aeruginosa, among patients admitted to the Erasmus University Medical Center since the first recorded case in 2003.
Secondary aims:
1.To investigate whether there is a difference in risk-factors between ICU and non-ICU patients in the Erasmus Medical Center. If that is the case, what are those differences?
2.To investigate whether Diversilab types are associated with specific risk-factors.(E.g. Diversilab types can be associated with medical materials used on various wards (ICU/non-ICU); prior carbapenem use; patient characteristics like age and sex etc.). (For example, males over the age of 50 have a higher odds (x) of acquiring Diversilab type B… when admitted on the ICU.. when having a urinary catheter and so on).
Study design
The time period in which cases are identified ranges from August 2003 till April 2015.
Intervention
Not applicable
Margreet C. Vos
Wytemaweg 80, Room Na-901k
Rotterdam 3015 CN
The Netherlands
0107033510
m.vos@erasmusmc.nl
Margreet C. Vos
Wytemaweg 80, Room Na-901k
Rotterdam 3015 CN
The Netherlands
0107033510
m.vos@erasmusmc.nl
Inclusion criteria
• VIM-2 positive culture after 48 hours after admittance in the Erasmus University Medidcal Center.
Exclusion criteria
• Children, because they are admitted at the Sophia Children’s Hospital and are separated from the Erasmus MC facilities. To our knowledge, there is no evidential cross-over potential of VIM-2 positive P. aeruginosa to the adult-care facilities.
• The outbreak resulting from Endoscopic Retrograde Cholangiopancreatography (ERCP). This outbreak has a known cause and is therefore reported and investigated separately (21).
• Patients only admitted at the Erasmus MC Cancer Institute . These patients are cared for in a separate building of the Erasmus MC and are therefore not be included in this study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4874 |
| NTR-old | NTR5145 |
| Other | : MEC-2015-240 |