No registrations found.
ID
Source
Brief title
Health condition
ow grade glioma (LGG) and diffuse pontine glioma (DIPG)
Sponsors and support
Intervention
Outcome measures
Primary outcome
To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect
changes in phospholipids and APT levels in paediatric brain tumours
Secondary outcome
· To investigate the use of non-invasive metabolic imaging to evaluate treatment effects of paediatric brain tumours;
· To investigate the use of non-invasive metabolic imaging to evaluate aggressiveness of paediatric brain tumours and if available compare it with histology and molecular biology
Background summary
Brain tumours are one of the leading causes of death in children. If possible, removing the tumour by surgery followed by radiotherapy and/or chemotherapy is nowadays the proposed treatment. But often the tumour cannot be removed and only chemo and/or radiation therapy are considered as treatment. During the treatment patients are monitored with structural imaging to evaluate response to therapy and its disease free survival. However, changes seen on imaging do not always reflect a change in tumour behaviour or growth; it might also reflect a reaction of the surrounding normal brain tissue on the treatment. From a diagnostic perspective, we are lacking a tool that can non-invasively identify tumour activity and indicate the aggressiveness of that piece of tumour. Information from metabolic processes in the tumour and surrounding tissue will help to understand tumour physiology, which will improve diagnosis and treatment evaluation, and may even help in choosing treatment strategy.
Objective: To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect changes in phospholipids and APT levels in paediatric brain tumours
Study objective
We hypothesize that information from metabolic processes in the paediatric brain tumour and surrounding tissue will help to understand tumour physiology, which will improve diagnosis and treatment evaluation.
Study design
01-03-2020: start inclusion
01-09-2021: end inclusion
01-03-2022: end study
Intervention
MRI at 7T
Inclusion criteria
- Children, 5-18 years diagnosed with a possible low grade glioma (LGG) or diffuse pontine glioma (DIPG)
- Children must be able to undergo MRI without anaesthesia;
- Informed and having given informed consent (either by patient and / or parents / legal guardian).
Exclusion criteria
- The presence of claustrophobia;
- Patients from who it is known at the time of inclusion that they will undergo tumour resection within 1 month;
- MRI-specific exclusion criteria, such as metal implants. Screening for MRI specific exclusion criteria will be done using the regular MRI (at 7 Tesla) safety screening.
- Refusal or inability to provide informed consent by patient and / or parent / legal guardian.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8285 |
| Other | METC Utrecht : METC 19/791 |