No registrations found.
ID
Source
Brief title
Health condition
Hypertension
Cerebral Small Vessel Disease (CSVD)
Hypertensie
Cerebrale wittestofschade
Sponsors and support
Intervention
Outcome measures
Primary outcome
cerebral blood flow velocity
Secondary outcome
cognitive functioning, white matter lesions, orthostatic hypotension, dynamic cerebral autoregulatory capacity, CO2 responsiveness, experienced side effects, disability to reach assigned BP target
Background summary
Pilot trial testing the effect of intensive control (SBP ≤120 mmHg) versus conventional targets (SBP<140-150 mmHg) on cerebral blood flow velocity in older (≤ 65 yrs) hypertensive patients with cerebral small vessel disease. Secondary objectives are to test the effect of tight blood pressure control on cognitive functioning, degree of white matter lesions and unacceptable side-effects of antihypertensive drugs.
Study objective
To test if intensive control (SBP ¡Ü120 mmHg) decreases cerebral blood flow velocity compared to conventional targets (SBP<140-150 mmHg) in PB in patients with CSVD and hypertension.
Study design
baseline, after 4 months of follow-up
Intervention
intensive control (SBP ≤120 mmHg)
Emma Kleipool
De Boelelaan 1117
Amsterdam 1081 HV
The Netherlands
020 444 2758
e.kleipool@vumc.nl
Emma Kleipool
De Boelelaan 1117
Amsterdam 1081 HV
The Netherlands
020 444 2758
e.kleipool@vumc.nl
Inclusion criteria
• ≥ 65 years of age
• High systolic blood pressure of 150-200mmHg based on the average of a daytime 24-hour BP (with or without taking antihypertensive medication)
• Cerebral small vessel disease (white matter lesions; Fazekas score ≥ 2) on MRI
Exclusion criteria
• Medical history of diabetes mellitus
• Experienced myocardial infarction within the past 12 months
• Medical history of stroke in the past 6 months or large (sub) cortical cerebral infarction on MRI
• Medical history of end stage heart failure (NYHA III-IV)
• Stage 4-5 kidney failure
• Diagnosed with dementia
• Life expectancy less than 1 year
• Unable to obtain an optimal window for TCD measurements during first visit at the outward patient clinic
• Significant stenosis (>70%) of the left of right common carotid artery
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6474 |
| NTR-old | NTR6661 |
| Other | METC VUmc : 2017.099 |