No registrations found.
ID
Source
Brief title
Health condition
Coronary atherosclerosis
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary aim of this explorative study is to compare exercise-induced cardiac
troponin elevations between athletes with different levels of coronary atherosclerosis.
Secondary outcome
The
secondary aim is to compare exercise responses to other cardiac biomarkers across
subgroups, whereas physiological and biochemical responses are assessed to gain more
insight in the potential underlying mechanisms of accelerated coronary atherosclerosis in
amateur athletes.
Background summary
In this study we want to compare exercise-induced cardiac troponin elevations between athletes with different levels of coronary atherosclerosis.
Study objective
We hypothesize that athletes with the
most severe coronary atherosclerosis show an exaggerated exercise-induced cardiac
biomarker elevation compared to athletes without coronary atherosclerosis.
Study design
Timepoints for blood withdrawal. Baseline (before exercise test), at 30 minutes during exercise and at 0/30/60/120 and 180 minutes after exercise cessation
Inclusion criteria
- Participation in MARC-2 study (so recent information about coronary atherosclerosis
is known).
- Availability of recent (<2 years) contrast enhanced coronary CT-scan data
- Willingness to be approached for participation in future research (as indicated on the
informed consent form of the MARC-2 study)
- Able to perform a ±1.5 hour exercise test on a bicycle
Exclusion criteria
- Unable to give informed consent
- Presence of a stent in any coronary artery or undergone coronary artery bypass
surgery
- Not cleared for exercise training by a cardiologist following the MARC-2 study
coronary CT-scan findings
- Absolute contra-indications for an exercise test (as indicated by the Standard
Operating Procedure guidelines of the department of Physiology)
- Participation in an interventional study targeting cardiovascular health
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8982 |
| CCMO | NL74326.091.20 |
| OMON | NL-OMON49634 |