No registrations found.
ID
Source
Brief title
Health condition
Neuroendocrine tumors
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcome parameter is the number of identified neuroendocrine tumors.
Secondary outcome
Secundary parameters are the tumor-to-background ratios measured in patients that recieved MB.
Background summary
Intraoperative identification of neuroendocrine tumors can be very challeging. Complete resection of the tumor is essential for curation. To reduce the number of patients with positive resection margins, near-infrared fluorescence imaging can be very usefull.
The aim of this study is test feasibility for intraoperative detection of neuroendocrine tumors using methylene blue and NIR fluorescence.
Study objective
Near-infrared fluorescent imaging can accurately detect neuroendocrine tumors non-invasively during surgical procedures.
Study design
The primary and secondary outcomes will be assessed during surgery and pathological assessment.
Intervention
Standard surgical procedure will be performed. During surgery, the near-infrared dye Methylene blue (MB) will be injected and the neuroendocrine tumor will be visualized non-invasively using our experimental camerasystem.
Department of Surgical Oncology,
P.O. Box 9600
C.J.H. Velde, van de
Leiden 2300 RC
The Netherlands
+31 (0)71 5262309
c.j.h.van_de_velde@lumc.nl
Department of Surgical Oncology,
P.O. Box 9600
C.J.H. Velde, van de
Leiden 2300 RC
The Netherlands
+31 (0)71 5262309
c.j.h.van_de_velde@lumc.nl
Inclusion criteria
1. Patients diagnosed with neuroendocrine tumors eligible to undergo a curative resection;
2. Age between 18 and 80 years old.
Exclusion criteria
1. Patients using SSRI's, SNRI's of TCA's;
2. Allergy to methyleen blue, history of severe renal impairment or G6PD-deficiency;
3. Patient pregnant or lactating.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL3558 |
| NTR-old | NTR3714 |
| Other | METC LUMC : P10.001 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |