No registrations found.
ID
Source
Brief title
Health condition
Alcohol dependence
Sponsors and support
Department of Psychiatry, Academic Medical Centre Amsterdam.
Intervention
Outcome measures
Primary outcome
fMRI indices of attentional processing of alcohol-associated images will be taken both before and after the end of the training regimen. Changes in neural effects will be one outcome variable.
Changes in biases to alcohol-associated stimuli will also be investigated.
Propensity to relapse and number of drinks consumed and frequency of alcohol use in the month following the training
Secondary outcome
Propensity to relapse and number of drinks consumed and frequency of alcohol use in the month following the training
Study objective
Training should affect attentional control processes specifically associated with alcohol-related stimuli. As a result, training as an additional treatment on top of CBT should reduce biases to alcohol-associated stimuli which have been linked with craving a relapse propensity. We expect that those individuals allocated to the training group should show reduced biases, also reflected as neuronal changes in the control of attention. Additionally the training should facilitate abstinence.
Study design
Participants register on the trial
Undergo the baseline assessment session at Time point 1
Over the next 6 time-points, they undergo online training
Time point 8 will be the post-training assessment session
One month after Time point 8, they will will in a questionnaire with information about the drinking behaviour during the month after the training.
Intervention
Attentional bias modification training or active placebo will be given at random and double blind to a group of alcohol dependent outpatients from clinics recruited in and around Amsterdam.
The real intervention is designed to train a person's ability to actively allocated attention to images of non-alcohol-containing beverages, while ignoring images of alcohol-containing drinks. thus the real training will involve training processes of attentional control in the presence of alcohol-associated images. On the other hand, the active placebo training condition will involve training attentional control processes more generally and not specific to alcohol-associated images.
All participants will receive a month of training, which is equivalent to 6 training sessions in total conducted over the internet.
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The Netherlands
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The Netherlands
Inclusion criteria
• Male and female patients, aged between 18-70 years
• Current DSM-V diagnosis of alcohol dependence
• Right-handed.
• Within the normal BMI range (18-30).
• Able to speak and understand Dutch.
• Able to speak and understand English.
Exclusion criteria
• Impairments in visual processing or in hand-eye coordination (this would make it difficult for patients to perform properly in the scanner)
• Being on any anti-craving medication (baclofen, acamprosate, naltrexone, disulfiram, or topiramate)
• No previous or current abuse of drugs other than alcohol (excluding nicotine, cannabis and caffeine)
• Pregnancy, trying to conceive or breastfeeding.
• Having any metal implants, working or having worked with metal, teeth braces or bridges, tattoos above the shoulder, or cardiac pacemaker.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5246 |
| NTR-old | NTR5503 |
| Other | AMC ethics number - NL49033.018.14 : ERAB Grant - EA1442 |