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ID
Source
Brief title
Health condition
paediatric cancer
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome will be the combined end point of a non-elective PICU admission or cardiopulmonary resuscitation.
Secondary outcome
The secondary outcomes of the study are hospital and PICU mortality; significant clinical deterioration event (a composite adverse outcome of the comprised treatment(s) provided in the 12 hours prior to transfer to PICU from an inpatient ward); hospital and PICU length of stay; rapid response team calls and urgent PICU consultations, and adherence to the BedsidePEWS scoring algorithm.
Background summary
Hospitalised paediatric oncology patients are at risk to develop acute complications. Early identification of clinical deterioration enabling adequate escalation of care remains challenging. Various Paediatric Early Warning Scores (PEWSs) have been evaluated, also in paediatric oncology patients but mostly in retrospective or case control study designs. This study encompasses the first prospective cohort to evaluate the predictive performance of the Bedside Paediatric Early Warning Score (BedsidePEWS) in hospitalised paediatric oncology patients for non-elective PICU admission or cardiopulmonary resuscitation. If the predictive value proves to be suboptimal, simultaneous collection of routine health care and patient monitor data enables us to fit a model for this particular high-risk population. Our ultimate goal is to provide a valuable prediction tool that timely detects critical deterioration in paediatric cancer patients, allowing for adequate (timing of) clinical intervention. This prospective cohort study is conducted at the Princess Máxima Centre, an 80-bed Dutch paediatric oncology hospital, directly connected to a shared 22-bed paediatric intensive care unit (PICU).
Study objective
We hypothesize that the BedsidePEWS might not have optimal predictive performance for clinical deterioration resulting in unplanned PICU transfer or cardiopulmonary resuscitation in hospitalised paediatric oncology patients and might need optimisation.
Study design
Prospective observational cohort study between Feb 1st 2019 and Sep 1st 2021 - continuous data collection.
Marijn Soeteman
06-22484486
m.soeteman-2@prinsesmaximacentrum.nl
Marijn Soeteman
06-22484486
m.soeteman-2@prinsesmaximacentrum.nl
Inclusion criteria
All patients with ICD-O diagnosis of paediatric malignancy, aged 0 - 18 years, admitted to one of the inpatient wards of the Princess Máxima Centre.
Exclusion criteria
Patients admitted as outpatients for routine diagnostic and therapeutic procedures will be excluded. Patients with restrictions in care (palliative care only, do not resuscitate orders, no PICU admission) will be excluded from the moment restriction in care is registered.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL8957 |
| Other | METC Utrecht : METC 16-572/C |