No registrations found.
ID
Source
Brief title
Health condition
Longaandoeningen welke kunstmatige beademingen behoeven
Respiratory failure in need of mechanical ventilation
Sponsors and support
Intervention
Outcome measures
Primary outcome
Incidence of patient-ventilator-asynchrony.
Secondary outcome
• Level and time course of incidence PVA.
• Time course of distribution of type of PVA.
• Level and time course of diaphragm EMG.
• Level and time course of intercostals EMG.
• Level and time course of phase angle distribution.
Background summary
Patient-ventilator asynchrony can lead to considerable patient distress, lead to increase used of sedatives. Surprisingly, relatively little is known about its incidence in mechanically ventilated children.
Currently, PVA can be detected in three different ways. At present, the most readily available method to detect PVA is analyzing the waveforms (the pressure-time, flow-time and volume-time waveform) displayed by the ventilator to detect PVA. However, for a true assessment of the occurrence of PVA it is mandatory to know if there is any patient effort before the ventilator delivers a breath. This can be most reliable method by detected by observing oesophageal pressure waveforms. Alternatively, electrical activity of the respiratory muscles has also been used to study PVA. EMG activity – especially of the diaphragm – also indicates patient effort. We hypothesized that the occurrence of PVA in mechanically ventilated children is higher than reported during visual inspection of the pressure – time and flow – time tracings when this is combined with non-invasive diaphragmatic and intercostal muscle EMG monitoring. Recruitment: the Netherlands
Study objective
The occurrence of PVA in mechanically ventilated children is higher than reported during visual inspection of the pressure – time and flow – time tracings when this is combined with non-invasive diaphragmatic and intercostal muscle EMG monitoring.
Study design
Daily recordings (2x15 minutes)
Intervention
n/a
Beatrix Children’s Hospital <br>
University Medical Center Groningen
R.G.T. Blokpoel
Groningen
The Netherlands
r.g.t.blokpoel@umcg.nl
Beatrix Children’s Hospital <br>
University Medical Center Groningen
R.G.T. Blokpoel
Groningen
The Netherlands
r.g.t.blokpoel@umcg.nl
Inclusion criteria
- all patients who require mechanical ventilation aged 0-18 years
- patients should be able to trigger the ventilator with a pre-set flow trigger of 1 liter/min
Exclusion criteria
- premature birth with gestational age corrected for post-conceptional age less than 40 weeks
- congenital or acquired neuromuscular disorders
- congenital or acquired central nervous system disorders with depressed respiratory drive
- severe traumatic brain injury (i.e. Glasgow Coma Scale < 8)
- congenital or acquired damage to the phrenic nerve
- congenital or acquired paralysis of the diaphragm
- use of neuromuscular blockade
- chronic lung disease
- severe pulmonary hypertension
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4350 |
| NTR-old | NTR4706 |
| Other | M13.143975 ID toegekend door lokale METc : Ped.PVA.EMG.1 Lokaal protocol nummer |