No registrations found.
ID
Source
Brief title
Health condition
glucose metabolism
Sponsors and support
Intervention
Outcome measures
Primary outcome
To investigate the effect of morning light exposure on postprandial glucose excursions and expression of metabolic and clock genes in adipose tissue.
Secondary outcome
To investigate the effect of morning light exposure on postprandial insulin excursions, postprandial free fatty acid (FFA) excursions, postprandial triglyceride levels, morning glucocorticoid increase, morning salivary melatonin decrease and measurements of skin temperature decrease and heart rate variability.
Background summary
N/A
Study objective
Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We hypothesize that mornig bright light exposure decreases postprandial glucose excursion in obese subjects with and without type 2 diabetes.
Study design
Frequent plasma measurements of glucose, insulin, C-peptide, free fatty acid and triglyceride. Adipose tissue biopsy at one timepoint. Continous measurement of heart rate variability and skin temperature.
Intervention
Subject will be admitted in the evening and receive a standard meal in normal room light. They sleep for 8 hours in the dark. From wake-up time they consume a standard liquid in bright or dim light.
Department of Endocrinology and Metabolism<br>
Academic Medical Center, Amsterdam
D.J. Stenvers
Amsterdam
The Netherlands
+31 (0)20 5663507
d.j.stenvers@amc.uva.nl
Department of Endocrinology and Metabolism<br>
Academic Medical Center, Amsterdam
D.J. Stenvers
Amsterdam
The Netherlands
+31 (0)20 5663507
d.j.stenvers@amc.uva.nl
Inclusion criteria
Group2
1. Age 18-80 years;
2. Male sex;
3. BMI >25 kg/m2
4. DM2: Fasting plasma glucose >6.9 mmol/L;
5. Habitual wake-up time between 6:00 and 9:00.
Exclusion criteria
1. Medication interfering with glucose metabolism or neuronal synaptic transmission;
2. Gastro-intestinal or metabolic disease that will interfere with digestion or metabolism;
3. Neuropsychiatric illness including severe depression;
4. Epilepsy;
5. Hypertension;
6. Ophthalmological abnormalities.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4141 |
| NTR-old | NTR4645 |
| Other | METC AMC : 2013_259 METC AMC |
Summary results
Smilde AK, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Bisschop PH. Acute
Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and
Men with Type 2 Diabetes. J Biol Rhythms. 2017 Apr;32(2):130-142. doi:
10.1177/0748730417693480. Epub 2017 Mar 20. PubMed PMID: 28470119; PubMed Central
PMCID: PMC5423535.