No registrations found.
ID
Source
Brief title
Health condition
Tourette syndrome
Tics
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study outcome is onset of tics (ONSET study) and tic exacerbation (COURSE study), as assessed by the Yale Global tic severity scale (YGTSS) plus Premonitory Urge for Tics Scale (PUTS).
Secondary outcome
Secondary parameters are the presence of obsessive-compulsive symptoms as assessed by the Children’s Yale Brown Obsessive-Compulsive Scale (CY-BOCS) and the presence of GAS in throat swabs.
Study objective
Presence of Group A streptococci in children's throat is associated with worsening or onset of tics
Study design
Assessments every four years during 16 months (COURSE) and 3 years (ONSET)
Intervention
None
Hanzeplein 1
P.J. Hoekstra
Groningen 9713 GZ
The Netherlands
p.j.hoekstra@med.umcg.nl
Hanzeplein 1
P.J. Hoekstra
Groningen 9713 GZ
The Netherlands
p.j.hoekstra@med.umcg.nl
Inclusion criteria
ONSET:
• First degree relative of person with TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association). This may include children with a half-sister/-brother with a tic disorder.
• Aged 3-10 years, male or female
Parents and patients have provided written informed consent and assent as appropriate according to ethical regulation
COURSE:
• TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association)
• Age 3 through 16 years, male or female
• Parents and patients have provided written informed consent and assent
Exclusion criteria
ONSET:
• Presence of tics. This will be checked by using the tic check list of the YGTSS.
• Current or previous presence of OCD
• Current or previous presence of trichotillomania
• Serious medical illness
• Child treated with antibiotics in the past 1 month.
• Children and/or parents are unable to understand and comply with protocol.
COURSE:
• Serious medical illness
• Child treated with antibiotics in the past 1 month
• Children and/or parents are unable to understand and comply with protocol
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4662 |
| NTR-old | NTR4814 |
| Other | European Commission : 278367 |